How Do Glycylcyclines Work?

Reviewed on 10/22/2021

WHAT ARE GLYCYLCYCLINES AND HOW DO THEY WORK?

Glycylcyclines are broad-spectrum antibiotics used to treat bacterial infections that are resistant to tetracyclines. They are bacteriostatic (prevent reproduction in bacteria) in nature and inhibit protein synthesis by binding to the A site of the bacterial ribosomal subunit 30s.

They maintain activity against tetracycline-resistant organisms, including resistant gram-positive organisms such as penicillin-resistant streptococcus pneumoniaemethicillin-resistant staphylococcus aureus, and staphylococcus epidermidis, and vancomycin-resistant enterococcus species.

Tigecycline is the first drug in this class of antimicrobials and is available only in an injectable form.

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HOW ARE GLYCYLCYCLINES USED?

Glycylcyclines are approved for the treatment of:

WHAT ARE SIDE EFFECTS OF GLYCYLCYCLINES?

Common side effects of glycylcyclines include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE DRUG NAMES OF GLYCYLCYCLINES?

Drug names include:

SLIDESHOW

MRSA Infection: Causes, Symptoms, and Treatment See Slideshow
References
https://reference.medscape.com/drugs/glycylcyclines

https://pubmed.ncbi.nlm.nih.gov/14723559/

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