How Do Hemostatics Work?

Reviewed on 8/4/2021

HOW DO HEMOSTATICS WORK?

Hemostatics are drugs that are administered intravenously during emergencies to reduce hemorrhage (bleeding from a ruptured blood vessel) and prevent death from hemorrhage within a hospital setting or any prehospital situations. There are several hemostatic agents such as prothrombin complex concentrate, recombinant clotting factors, and other agents each with a different mechanism to induce hemostasis (stop bleeding from a blood vessel). They include:

  • Concentrating coagulation factors
  • Adhesion to the tissues where traumatic hemorrhage occurred
  • Delivering procoagulant factors to the hemorrhage site

Our body naturally produces clotting factors to stop blood loss during any injury such as accident or combat injury. However, patients with congenital diseases such as Von Willebrand disease (VWD) and hemophilia lack clotting factors. They are classified as:

  • Hemophilia a: clotting factor VIII deficiency
  • Hemophilia b: clotting factor IX deficiency
  • Hemophilia c: clotting factor XI deficiency
  • VWD: low levels or defective Von Willebrand factor proteins that does not work to form clots

Some patients may develop coagulation disorders because of the following factors:

HOW ARE HEMOSTATICS USED?

Hemostatics are given intravenously to treat uncontrollable massive bleeding in the absence of clotting factors or in the presence of coagulation disorders. They are also used to treat:

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WHAT ARE SIDE EFFECTS OF HEMOSTATICS?

Side effects associated with hemostatics include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF HEMOSTATICS?

Generic and brand names of hemostatic drugs include:

References
https://reference.medscape.com/drugs/hemostatics

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869418/

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