How Do HSV Antivirals Work?

Reviewed on 10/22/2021

HOW DO HSV ANTIVIRALS WORK?

Herpes simplex virus (HSV) antivirals are used to treat herpes simplex virus 1 and 2 (HSV-1 and HSV-2). Acyclovir is the antiviral most commonly used to treat HSV infections. It works by inhibiting DNA synthesis and therefore prevents replication of the virus. HSV-1 is transmitted by oral-to-oral contact, mainly causes oral herpes known as cold sores, and may also cause genital herpes. HSV-2 is a sexually transmitted disease that causes genital herpes. Herpes infections are highly contagious; oral and genital herpes is usually asymptomatic, and if symptomatic, painful blisters or ulcers appear at the site of infection. HSV-2 infection increases the risk of acquiring and transmitting human immunodeficiency virus infection.

Acyclovir is converted into acyclovir monophosphate by viral thymidine kinase enzyme, which is then converted into acyclovir triphosphate (ACV-TP) by the host cell kinases. The formed ACV-TP competitively inhibits and inactivates HSV DNA polymerase and prevents viral DNA synthesis and replication of the virus.

HOW ARE HSV ANTIVIRALS USED?

HSV antivirals are used to treat HSV-1 and HSV-2 infections.

QUESTION

Is genital herpes contagious? See Answer

WHAT ARE SIDE EFFECTS OF HSV ANTIVIRALS?

Side effects associated with HSV antivirals include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF HSV ANTIVIRALS?

Generic and brand names of HSV antiviral drugs include:

References
https://reference.medscape.com/drugs/antivirals-hsv

https://www.rxlist.com/zovirax-drug.htm

https://www.ncbi.nlm.nih.gov/books/NBK47444/

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