The signs and symptoms of anus or anal cancer are often similar to more common and less serious conditions affecting the anus, such as piles (hemorrhoids) and tears in the lining of the anus called anal fissures. A few warning signs and symptoms of anal cancer are
- Rectal bleeding, often minor, is one of the first signs of anal cancer. Often, a person mistakenly thinks the bleeding is caused by hemorrhoids.
- Noticeable changes in bowel habits (having more or fewer bowel movements or increased straining during a bowel movement)
- Itching, swelling, pain, burning around the anus or rectum
- Leakage of fluid or mucus discharge from the anus
- Loss of bowel control (fecal incontinence)
- Lumps felt on or around the anus
- Feelings of pain or pressure in or around the anus
- Recurrent presence of anal abscesses or pockets of pus
- Swollen lymph nodes in the anal or groin area
- Narrower stools
- A sense of fullness and constant need to go to the washroom
- A few patients may also complain of lower back pain
- Women may experience vaginal dryness
What is anal cancer?
Anal cancer or anal carcinoma is a rare type of cancer that starts in the cells lining the anus, the opening that connects the lower part of the large intestine (rectum) to the outside of the body through which waste passes. There are different types of anal cancer. They are:
- Squamous cell carcinoma:
- These develop from the cells that produce mucus within the anal canal.
- Basal cell carcinoma:
- Malignant melanoma:
The exact cause of anal cancer is unknown. Possible risk factors of anal cancer are:
- Human papillomavirus (HPV) infection is the most common cause. It affects the moist membranes or lining of the body. Having anal sex may usually increase the risk of developing an HPV infection.
- Having a history of other cancers, such as cervical cancer, vaginal or vulval cancer.
- Smoking is often considered a risk factor for developing almost any type of cancer.
- People who take drugs to suppress their immune systems (immunosuppressive drugs), including people who have received organ transplants may have an increased risk of anal cancer. Diseases, such as human immunodeficiency virus (HIV) infection, may also suppress the immune system and increase the risk of anal cancer.
- The risk of developing anal cancer increases with age. 50 percent of anal cancer cases diagnosed are in people aged 65 years or older.
- More common in women than men. However, more African-American males get anal cancer than females.
- The presence of anal fistulas or abnormal openings in the anus and frequent swelling in or around the anus or rectum.
- People who have had anal warts are more likely to get anal cancer. These are noncancerous growths that may occur just outside the anus and in the lower anal canal. They are caused by infection with human papillomavirus (HPV).
- Other things that can increase the risk for anal cancer include having multiple sex partners and poor social or living conditions.
- Local resection: If the tumor is small and has not spread, the surgeon may choose to remove the tumor and some of the tissue surrounding the anus. The muscles surrounding the area are spared (if possible) to allow control of bowel movements after recovery.
- Abdominoperineal resection: In this procedure, a surgeon removes the anus, rectum and part of the colon. The intestine is redirected to an opening in the abdomen, called a stoma. A special bag is attached to the stoma to collect waste in place of the body’s normal bowel movements. During surgery, the surgeon may also remove lymph nodes surrounding the area to determine whether they contain cancer. This type of surgery is often required for large tumors or those that have grown into the abdominal wall.
- External radiation therapy: It uses a machine outside the body to send radiation toward the cancer site.
- Internal radiation therapy: Internal radiation therapy uses a radioactive substance sealed in needles, seeds, wires or catheters that are placed directly into or near the cancer site.
It uses specialized drugs to stop the growth of cancer cells either by destroying the cells or by preventing them from making new cells.
Anal cancer is a serious disease. However, treatments are effective, and most people can be cured. About 50 percent of anal cancers are diagnosed before the cancer has spread beyond the anus. The five-year survival rate for localized anal cancer is 80 percent.