How Do Lincosamide Antibiotics Work?

Reviewed on 6/29/2021

HOW DO LINCOSAMIDE ANTIBIOTICS WORK?

Lincosamides are a class of antibiotics used to treat bacterial infections such as pelvic inflammatory disease, abdominal infections, abscess, acne, and anaerobic infections. They are usually used to treat severe infections in patients who are allergic to penicillin. Lincosamides are bacteriostatic agents; they prevent bacterial replication by interfering with the protein synthesis and may also demonstrate bactericidal (kill bacteria) activity against certain organisms at high antibiotic concentrations.

Once inside the bacterial cell, lincosamide antibiotics bind to the 50S ribosomal subunit at the region overlapping A and P sites of the ribosome, exclusively through contact with 23S ribosomal RNA close to peptidyl transferase cavity. This results in inhibition of peptidyl transferase enzyme because of which the docking of charged transfer RNA and their movement through the peptidyl transferase center is prevented and protein is not synthesized.

HOW ARE LINCOSAMIDE ANTIBIOTICS USED?

Lincosamide antibiotics are effective against gram-positive bacteria, anaerobic infections, and protozoal diseases, but they have little to no effect on gram-negative bacteria. They are effective in treating infections, including:

QUESTION

Bowel regularity means a bowel movement every day. See Answer

WHAT ARE SIDE EFFECTS OF LINCOSAMIDE ANTIBIOTICS?

Side effects of lincosamide antibiotics may include:

Serious side effects of lincosamide antibiotics may include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF LINCOSAMIDE ANTIBIOTICS?

Generic and brand names of lincosamide antibiotics include:

References
https://reference.medscape.com/drugs/antibiotics-lincosamide

https://pubmed.ncbi.nlm.nih.gov/27940264/

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