How Do Lipopeptides Work?

Reviewed on 4/28/2021

What Are Lipopeptides and How Do They Work?

Lipopeptides are molecules produced by microorganisms (soil bacteria and fungi) as part of their metabolism. Lipopeptides are used as antibiotics and antifungal and antitumor agents. They consist of a lipid connected to a peptide (short chains of amino acids linked by peptide bonds) and can self-assemble into different structures.

Lipopeptides exert their effect by binding and disrupting the cell membrane integrity of the target bacteria and initiating a series of events that eventually leads to cell death.

Lipopeptides are given as intravenous infusions and are not recommended for use in children aged below 12 months because of possible serious side effects.

How Are Lipopeptides Used?

Uses of Lipopeptides include:

What Are Side Effects of Lipopeptides?

Common side effects include:

Other rare side effects include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

SLIDESHOW

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What Are Drug Names of Lipopeptides?

Drug names of lipopeptides include:

References
Medscape. Lipopeptides.

https://reference.medscape.com/drugs/lipopeptides

ScienceDirect. Lipopeptide Antibiotic.

https://www.sciencedirect.com/topics/chemistry/lipopeptide-antibiotic

NCBI. Mechanism of Action and Resistance to Daptomycin in Staphylococcus aureus and Enterococci.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088507/

The Royal Society of Chemistry. Lipopeptides: from self-assembly to bioactivity

https://pubs.rsc.org/en/content/articlehtml/2015/cc/c5cc01535a

NCBI. Cyclic lipodepsipeptides: a new class of antibacterial agents in the battle against resistant bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845972/

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