How Do MAO Type B Inhibitors Work?

MAO type B inhibitors are a class of drugs used to treat Parkinson’s disease symptoms.

The direct cause of Parkinson's disease or Parkinsonian-like syndrome is the deficiency of the neurotransmitter dopamine in the brain. Antiparkinson medicines aim to prolong the action of dopamine in the brain by:

• Replacing dopamine
• Inhibiting dopamine breakdown
• Sensitizing dopamine receptors to stimulate dopamine release

MAO type B inhibitors treat the symptoms of Parkinson's disease by blocking an enzyme called monoamine oxidase-type B (MAO-B). MAO-B breaks down several chemicals in the brain, including dopamine. By blocking MAO-B, the drugs prevent the breakdown of dopamine, resulting in prolonged action of dopamine in the brain.

MAO type B inhibitors are beneficial when given as a monotherapy in the initial stages of Parkinson’s disease. Besides, they can be given as an adjunct to other medications, including levodopa. These inhibitors are given as monotherapy to treat the following symptoms of Parkinson’s disease:

• Slowness
• Stiffness
• Tremors

Some of the common side effects of MAO type B inhibitors include:

• Mild nausea
• Dry mouth
• Lightheadedness
• Constipation
• Confusion
• Hallucinations
• Insomnia
• Dyskinesia (uncontrolled, involuntary muscle movements)
• Anxiety
• Cough
• Indigestion
• Rash

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

Generic and brand names of MAO type B inhibitors include:

• Azilect
• Eldepryl
• Emsam
• Rasagiline
• Safinamide
• Selegiline
• Selegiline transdermal
• Xadago
• Zelapar