How Do Monobactams Work?

Reviewed on 5/3/2021

What Are Monobactams and How Do They Work?

Monobactams are a subgroup of beta-lactam antibiotics, wherein the beta-lactam ring is alone and not fused to another ring (in contrast to other beta-lactams which have at least two rings).

Monobactams work only against aerobic gram-negative bacteria (Neisseria, Pseudomonas).

Monobactams work by inhibiting the peptidoglycan synthesis process (a process essential to maintain bacterial cell wall integrity); as a result, the bacteria lose the ability to resist and burst, leading to cell death.

Monobactam antibiotics are administered intravenously or intramuscularly.

How Are Monobactams Used?

Monobactams are used to treat the following:

Side Effects of Monobactams

Common side effects include:

Other rare side effects include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

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Names of Monobactam Drugs

Names of Monobactam drugs include:

  • Azactam
  • Aztreonam
  • Aztreonam inhalation
  • Cayston
References
Medscape. Monobactams.

https://reference.medscape.com/drugs/monobactams

ScienceDirect. Monobactam.

https://www.sciencedirect.com/topics/neuroscience/monobactam

Mayo Clinic Proceedings. The Monobactams.

https://www.mayoclinicproceedings.org/article/S0025-6196(12)65797-8/fulltext

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