How Do Nephrolithiasis Drugs Work?

Reviewed on 12/6/2021

How do nephrolithiasis drugs work?

Nephrolithiasis drugs are medications used to prevent the formation of kidney stones (nephrolithiasis) and to alkalinize the urine and promote base and acid elimination in the urine. Nephrolithiasis drugs work in different ways to prevent kidney stone formation.

Kidney stones form due to minerals and other substances forming crystals and getting deposited in the kidney instead of getting reabsorbed or eliminated in the urine. Nephrolithiasis drugs work in the following ways:

  • Prevent cystine stone formation by making cystine more water-soluble and reducing its concentration in the urine. Cystine is an amino acid that is a building block for most proteins.
  • Prevent calcium stone formation by binding to the calcium in the urine.
  • Prevent the formation of urate crystals from uric acid by raising the pH level and alkalinizing the urine.

How are nephrolithiasis drugs used?

Nephrolithiasis drugs are administered as oral tablets or solutions, approved by the FDA to treat the following conditions:

  • Prevention of nephrolithiasis
  • Alkalinization of the urine

What are side effects of nephrolithiasis drugs?

Side effects of nephrolithiasis drugs may include the following:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What are names of nephrolithiasis drugs?

Generic and brand names of nephrolithiasis drugs include:

  • Albrights Solution
  • Bicitra
  • Cytra 2
  • Oracit
  • Shohls Solution
  • sodium citrate/citric acid
  • Thiola
  • Thiola EC
  • tiopronin
  • Tiopronin DR
  • Tiopronin-K DR

SLIDESHOW

Kidney Stones: Symptoms, Causes, and Treatment See Slideshow
References
https://reference.medscape.com/drugs/nephrolithiasis

https://www.kidney.org/atoz/content/kidneystones_prevent

Health Solutions From Our Sponsors