How Do Neprilysin Inhibitors Work?

Reviewed on 5/6/2021

How Do Neprilysin Inhibitors Work?

Neprilysin inhibitors are a new class of drugs used to treat high blood pressure and heart failure. They work by blocking the action of neprilysin thus preventing the breakdown of natriuretic peptides.

Neprilysin enzyme is also called neutral endopeptidase that plays a role in the degradation of natriuretic peptides and other vasoactive peptides including bradykinin. Natriuretic peptides remove sodium from the blood and excrete it in the urine. In the absence of natriuretic peptides, sodium levels increase in the blood, leading to increased blood pressure.

Bradykinin is a vasodilator that relaxes and widens the walls of blood vessels. This facilitates the free flow of blood in the vessels. In the absence of bradykinin, the blood vessels may not relax and may cause an increase in blood pressure.

Neprilysin inhibitor increases the availability of natriuretic peptides, helps bradykinin to achieve vasodilation and natriuresis (excretion of sodium), and decreases blood pressure.

How Are Neprilysin Inhibitors Used?

Neprilysin inhibitors are used to treat:

What Are Side Effects of Neprilysin Inhibitors?

Common side effects include:

Serious side effects may include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What Are Drug Names of Neprilysin Inhibitors?

Drug names include:


In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer

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