How Do Neuraminidase Inhibitors Work?

Reviewed on 5/10/2021

How Do Neuraminidase Inhibitors Work?

Neuraminidase inhibitors are antiviral drugs used to treat acute respiratory infections and influenza (a highly contagious viral infection that affects the respiratory system and is a major cause of morbidity and mortality).

All influenza viruses contain two glycoproteins, hemagglutinin, and neuraminidase (a protein essential for invading the new host cells). Neuraminidase inhibitors block the function of the viral neuraminidase protein, thus stopping the release of viruses from the infected host cells and preventing new host cells from being infected, and therefore, the infection does not spread in the respiratory tract.

The replication of the influenza virus reaches its peak between 24 to 72 hours after the onset of symptoms. Neuraminidase inhibitors should be given as early as possible (within 48 hours of symptom onset).

As neuraminidase inhibitors are effective against all strains of influenza and can be used as a prophylaxis (although not as a substitute for vaccination), they play a key role in the preparedness of epidemics and pandemics.

How Are Neuraminidase Inhibitors Used?

Neuraminidase inhibitors are used to treat:

  • Influenza (A and B)
  • As a treatment
  • As a prophylaxis
  • Viral pneumonia
  • Swine flu
  • Postexposure prophylaxis (within 7 days of exposure)
  • Pre-exposure prophylaxis (at the time of community outbreaks)

SLIDESHOW

How to Get Rid of a Cold: Natural Remedies See Slideshow

What Are Side Effects of Neuraminidase Inhibitors?

Most of the minor side effects occur only once at the initiation of therapy and resolve within 1 to 2 days.

The common side effects include:

Other rare side effects include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What Are Names of Neuraminidase Inhibitors Drugs?

Names of neuraminidase inhibitors include:

References
https://reference.medscape.com/drugs/neuraminidase-inhibitors

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC113777/

https://www.cdc.gov/mmwr/preview/mmwrhtml/rr4814a1.htm

https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/neuraminidase-inhibitors

https://www.nejm.org/doi/full/10.1056/NEJMra050740

Health Solutions From Our Sponsors