How Do Ophthalmic Antibiotics/Corticosteroids Work?

Reviewed on 5/13/2021

How Do Ophthalmic Antibiotics/Corticosteroids Work?

Ophthalmic antibiotic/corticosteroid combinations are effective against inflammation as well as bacterial infection in the eyes. Antibiotics kill bacteria and prevent their growth, while corticosteroids are anti-inflammatory and work by reducing swelling and irritation in the eyes.

Inflammation results when the body’s immune system releases pro-inflammatory proteins (cytokines) that flow out through the tiny blood vessels (capillaries) to fight the bacteria at the infection site. Corticosteroids decrease capillary permeability, prevent the cytokines from flowing out of the capillaries, and relieve the symptoms of inflammation.

Ophthalmic antibiotics work by killing the bacteria that entered the eye and caused the infection and inhibit bacterial growth in the following ways:

  • Create fissures in the bacterial cell membrane, causing cell contents to leak out, and enable absorption of the antibiotic into the bacterial cell
  • Prevent the bacteria from using amino acids and enzymes to synthesize proteins and folic acid required for their survival
  • Prevent the growth of bacterial cell walls, the layer over the bacterial cell membrane, which protects them when they grow and helps maintain their shape

What Are Uses of Ophthalmic Antibiotics/Corticosteroids?

Ophthalmic antibiotic/corticosteroid drugs are topical applications administered in the eyes, in the form of ointments or suspensions.

Ophthalmic antibiotics/corticosteroids are used to treat conditions that include:

  • Conjunctivitis (inflammation of the conjunctiva which includes the whites of the eye and the inner surface of eyelids)
  • Steroid-responsive inflammation in the eyes with an existing bacterial infection or a risk for developing bacterial infection

What Are Side Effects of Ophthalmic Antibiotics/Corticosteroids?

Side effects of ophthalmic antibiotics/corticosteroids may include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

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What are names of some ophthalmic antibiotic/corticosteroid drugs?

Generic and brand names of ophthalmic antibiotic/corticosteroid drugs include:

References
https://reference.medscape.com/drugs/antibiotics-corticosteroids-ophthalmic

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