How Do Other Cough/Cold Combos Work?

Reviewed on 1/6/2022

How do other cough/cold combos work?

Other cough/cold combos include different combinations of medications that are used in the treatment of common conditions such as cough, cold, flu, sinus congestion, and headaches. Each medication in the combo works in unique ways to relieve congestion, fever, headache, and other minor aches and pains.

Other cough/cold combos are formulations of analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), expectorants, and decongestants in various combinations. Other cough/cold combos may combine two or more of the following medications:

Other cough/cold combos commonly available include the following:

  • Acetaminophen/guaifenesin
  • Acetaminophen/phenylephrine
  • Acetaminophen/pseudoephedrine
  • Acetaminophen/phenylephrine/guaifenesin
  • Acetaminophen/pseudoephedrine/guaifenesin
  • Phenylephrine/guaifenesin
  • Guaifenesin/pseudoephedrine
  • Ibuprofen/phenylephrine
  • Ibuprofen/pseudoephedrine
  • Naproxen/pseudoephedrine


A Cold or The Flu? How to Tell the Difference See Slideshow

What are the uses of other cough/cold combos?

Other cough/cold combos are available over the counter in different strengths and formulations in the form of oral tablets, capsules, caplets, solutions, liquids, and syrups. Cough/cold combos may be used to treat the following:

  • Cough
  • Fever
  • Headache
  • Minor aches and pains
  • Flu symptoms
  • Nasal congestion
  • Sinus congestion and headaches
  • Congestion with mucus
  • Allergic cold

What are side effects of other cough/cold combos?

Side effects of other cough/cold combos may vary with each type of drug. Side effects may include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What are names of some of the other cough/cold combos?

Generic and brand names of some of the other cough/cold combos include:

  • acetaminophen/guaifenesin
  • acetaminophen/phenylephrine
  • acetaminophen/phenylephrine/guaifenesin
  • acetaminophen/pseudoephedrine
  • acetaminophen/pseudoephedrine/guaifenesin
  • Advil Cold and Sinus
  • Advil Congestion Relief
  • Aleve-D Sinus & Headache
  • Allerest Allergy and Sinus Relief
  • Children's Tylenol Cold Daytime
  • Comtrex Deep Chest Cold Non-Drowsy
  • Congestac
  • Excedrin Sinus Headache
  • Genatap Sinus Maximum Strength
  • guaifenesin/pseudoephedrine
  • Guaifenex PSE
  • ibuprofen/phenylephrine
  • ibuprofen/pseudoephedrine
  • Mapap Sinus Maximum Strength
  • Medi-Synal
  • Mucinex D
  • Mucinex Fast-Max Cold & Sinus
  • naproxen/pseudoephedrine
  • Omex
  • Oranyl Plus
  • phenylephrine/guaifenesin
  • QlearQuil Daytime Sinus & Congestion Relief
  • Refenesen Plus
  • Robitussin Peak Cold Nasal Relief
  • Sine-Off Non-Drowsy Maximum Strength Tablets
  • Sinus-Relief
  • Sinutab Non-Drying
  • Sinutab Sinus Maximum Strength Tablets
  • Sudafed PE Non-Drying Sinus Caplets
  • Sudafed PE Sinus Headache
  • Sudafed PE Triple Action
  • Sudafed Triple Action
  • Theraflu Warming Relief Cold & Chest Congestion
  • Tylenol Chest Congestion
  • Tylenol Chest Congestion Daytime Non-Drowsy
  • Tylenol Cold Daytime
  • Tylenol Infants Drops Plus Cold
  • Tylenol Sinus Congestion & Pain Daytime
  • Tylenol Sinus Congestion & Pain Severe
  • Tylenol Sinus Daytime
  • Tylenol Sinus Severe Congestion Daytime
  • Vicks DayQuil Sinus


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