How Do Otic Antibiotics/Corticosteroids Work?

Reviewed on 6/24/2021

How do antibiotics/corticosteroids work?

Otic antibiotic/corticosteroid combinations are used to treat inflammation and bacterial infection in the ears. Antibiotics kill bacteria and control infection, while corticosteroids suppress the inflammatory response to infection and relieve symptoms such as pain, swelling and irritation.

Antibiotics work in different ways to kill bacteria and clear the infection. Some antibiotics damage the bacterial cell membrane, some prevent the bacteria from synthesizing proteins required for their growth and some inhibit gyrase, an enzyme essential for bacterial DNA replication, promoting DNA strand breakage and cell death.

The immune system reacts to infection with the release of inflammatory proteins (cytokines) that leak out of the tiny blood vessels (capillaries) in the ear to fight the infection. Corticosteroids suppress the immune response by inhibiting cytokine release and decreasing the capillary permeability, which prevents the cytokines from leaking out.

Antibiotic/corticosteroid drug formulations may have one or more antibiotics combined with corticosteroids. Corticosteroids may also be combined with anti-infectives such as alcohol or acetic acid. Some drug formulations contain substances that improve absorption into the ear tissue.

Antibiotic/corticosteroid drugs are effective against ear infections caused by bacteria that include:

How are otic antibiotics/corticosteroids used?

Otic antibiotics/corticosteroids are solutions or suspensions that are administered into the ear canal. Otic antibiotics/corticosteroid combinations are used to treat the following ear conditions:


Ear infection or acute otitis media is an infection of the middle ear. See Answer

What are side effects of otic antibiotics/corticosteroids?

Side effects of otic antibiotics/corticosteroids may include:

Otic side effects:

Systemic side effects:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What are names of some otic antibiotic/corticosteroid drugs?

Generic and brand name of otic antibiotic/corticosteroid drugs include:


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