How do otic corticosteroids work?
Otic corticosteroids are medications used to treat non-infectious ear inflammation. Corticosteroids suppress inflammation and relieve symptoms such as pain, swelling and itching. Non-infectious ear inflammation may be caused by contact with jewelry or cosmetic products, or inflammatory conditions such as eczema or psoriasis.
In response to skin irritation, the immune system promotes inflammation by releasing pro-inflammatory proteins (cytokines) that leak out of the tiny blood vessels (capillaries) in the ear tissue. Corticosteroids suppress the immune response by inhibiting the release of cytokines and also decreasing the capillary permeability to prevent cytokines from leaking out.
How are otic corticosteroids used?
Otic corticosteroids are otic oils that are administered into the ear canal to treat non-infectious inflammation caused by a condition known as eczematous external otitis or external ear eczema. Eczematous external otitis is a chronic inflammatory condition of the external ear which causes symptoms such as scaling, redness, swelling, itching, pain and discharge.
What are side effects of otic corticosteroids?
Side effects of otic corticosteroids may include:
Otic side effects:
Systemic side effects:
- Acne eruptions
- Loss of skin pigmentation (hypopigmentation)
- Perioral dermatitis
- Allergic contact dermatitis
- Skin damage (atrophy)
- Scarring of skin (striae)
- Prickly heat (miliaria)
Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.