How Do P-selectin Inhibitors Work?

How Do P-selectin Inhibitors Work?

P-selectin inhibitors are a class of drugs used for treating the obstruction of blood flow caused due to sickle cell disease (group of inherited red blood cell disorders that affects hemoglobin, the protein that carries oxygen through the body)

Sickle cell disease is caused due to overproduction of P-selectin. P-selectin is a protein produced by blood components, such as platelets, that helps the cells stick together. Due to the overproduction of P-selectin, more and more blood cells stick together to form a cluster in the bloodstream. The clustering of cells can lead to a state called vaso-occlusion, which obstructs blood flow to the organs and other areas of the body.

P-selectin inhibitors block the action of P-selectin and prevent the clustering of cells.

How Are P-selectin Inhibitors Used?

P-selectin inhibitors relieve obstruction of blood flow associated with sickle cell disease.

What Are Side Effects of P-selectin Inhibitors?

Some of the side effects of P-selectin inhibitors include:

  • Nausea
  • Joint pain
  • Back pain
  • Fever
  • Abdominal pain
  • Diarrhea
  • Vomiting
  • Itching
  • Muscle pain
  • Infusion-site reaction 

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What Are Names of P-selectin Inhibitors?

Generic and brand names of P-selectin inhibitors include:

  • Adakveo
  • Crizanlizumab
  • Crizanlizumab-tmca

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