How Do PDE-3 Inhibitors Work?

Reviewed on 8/4/2021

HOW DO PDE-3 INHIBITORS WORK?

Phosphodiesterase-3 (PDE-3) inhibitors are medications used to prevent and treat platelet aggregation and intermittent claudication (cramping in the legs because of decreased blood flow during exercise or walking).

PDE-3 inhibitors work by inhibiting the enzyme phosphodiesterase and prevent the breaking down of intracellular secondary messengers, cyclic adenosine monophosphate (cAMP), and cyclic guanosine monophosphate (cGMP) molecules leading to an increase in the levels of cAMP and cGMP in the cells.

Increased cAMP molecules decrease the levels of calcium in the smooth muscle cells. cAMP also inhibits the enzyme myosin light chain kinase that causes contraction of the smooth muscle. So, increased cAMP promotes dilation of blood vessels.

cAMP and cGMP strongly inhibit the normal platelet function. Increased cAMP in the platelets increases the active form of an enzyme, protein kinase A (PKA). PKA is directly associated with inhibition of platelet aggregation and prevention of clot formation.

HOW ARE PDE-3 INHIBITORS USED?

PDE-3 inhibitors are used to treat:

WHAT ARE SIDE EFFECTS OF PDE-3 INHIBITORS?

Side effects associated with PDE-3 inhibitors include:

Other rare but serious side effects of PDE-3 inhibitors may include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

SLIDESHOW

Spider & Varicose Veins: Causes, Before and After Treatment Images See Slideshow

WHAT ARE NAMES OF PDE-3 INHIBITORS?

Generic and brand names of PDE-3 inhibitor drugs include:

References
https://reference.medscape.com/drugs/pde-3-inhibitors

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195739/

Health Solutions From Our Sponsors