How Do Phospholipase A2 Inhibitors Work?

Reviewed on 8/10/2021

HOW DO PHOSPHOLIPASE A2 INHIBITORS WORK?

Phospholipase A2 (PLA2) inhibitors are drugs used to treat conditions associated with excessive platelet production and aggregation of platelets such as peripheral vascular disease. These drugs work by inhibiting the PLA2 enzyme that hydrolyzes membrane phospholipids into lysophospholipids which are converted to platelet-activating factors.

 

Anagrelide, a PLA2 inhibitor works (reduces platelet production) by inhibiting the maturation of platelets from megakaryocytes. The exact mechanism of action is unclear, although it is known to be a potent phosphodiesterase II inhibitor and inhibit phosphodiesterase type 3 (PDE3).

Cilostazol is a selective inhibitor of PDE3. It increases cyclic adenosine monophosphate, which increases the active form of protein kinase A, directly associated with an inhibition of platelet aggregation.

HOW ARE PHOSPHOLIPASE A2 INHIBITORS USED?

PLA2 inhibitors are used to treat:

WHAT ARE SIDE EFFECTS OF PHOSPHOLIPASE A2 INHIBITORS? 

Side effects of PLA2 inhibitors may include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF PHOSPHOLIPASE A2 INHIBITORS?

Generic and brand names of PLA2 inhibitors include:

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References
https://reference.medscape.com/drugs/phospholipase-a2-inhibitors

https://pubmed.ncbi.nlm.nih.gov/25891385/

https://www.ncbi.nlm.nih.gov/books/NBK544363/

https://pubchem.ncbi.nlm.nih.gov/compound/Anagrelide

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