How Do Pleuromutilins Work?

Reviewed on 10/22/2021

What Are Pleuromutilins?

Pleuromutilins are a class of antibacterial substances that work by inhibiting the synthesis of protein in bacteria. Pleuromutilins were discovered in the 1950s mainly for veterinary purposes; however, a new derivative of pleuromutilin was introduced in 2019 for human use. Due to the unique mechanism of this drug, drug resistance is rarely seen with pleuromutilins.

What Are Uses of Pleuromutilins?

Pleuromutilins are mainly effective against gram-positive and gram-negative bacteria. They are mainly used for:

Topical application of pleuromutilins may occasionally cause skin irritation.

What Are Side Effects of Pleuromutilins?

Pleuromutilins, when administered orally or intravenously, may show some adverse effects, including:

Some rare side effects include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor. Also, irrational use of antibiotics can increase your risk of getting an infection later that resists antibiotic treatment.

What Are Name of Pleuromutilins Drugs?

Pleuromutilins Drugs Names Are:


Bowel regularity means a bowel movement every day. See Answer
Medscape. Pleuromutilin.

NCBI. Pleuromutilins: Potent Drugs for Resistant Bugsā€”Mode of Action and Resistance.

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