How Do Potassium-Sparing Diuretics Work?

Reviewed on 6/15/2021

WHAT ARE POTASSIUM-SPARING DIURETICS AND HOW DO THEY WORK?

Diuretics also known as water pills are a class of drugs that cause diuresis (increased production of urine by the kidneys). Diuretics are drugs that work on the kidneys to remove electrolytes such as sodium and chloride from the body in the urine. These electrolytes draw water along with them; thus, excess water also gets eliminated in the urine. They are used to treat conditions associated with the presence of excess sodium and water in the body such as hypertension and fluid overload in the body that may damage major organs such as the heart and cause edema (accumulation of fluid in the body tissues causing swelling, usually seen due to damage to the small vessels).

Potassium-sparing diuretics are drugs that cause the excretion of sodium and water while preventing the loss of potassium in the urine. There are several drugs in this class, and each has a different mechanism of action.

  • Sodium channel inhibition: some drugs work by inhibiting sodium channels on the distal part of the nephron, distal tubule, and collecting ducts where the sodium is reabsorbed. As these channels are blocked, the uptake of sodium is blocked and transepithelial potential is not generated; thus, the excretion of potassium is decreased.
  • Aldosterone antagonism: aldosterone is a hormone that increases the reabsorption of sodium and water. These drugs inhibit aldosterone activity by binding to aldosterone receptors present on the collecting ducts and decrease the reabsorption of sodium and water.
Potassium-sparing diuretics are considered weak diuretics that are usually given along with other diuretics.

HOW ARE POTASSIUM-SPARING DIURETICS USED?

Potassium-sparing diuretics are used for:

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WHAT ARE SIDE EFFECTS OF POTASSIUM-SPARING DIURETICS?

The side effects associated with potassium-sparing diuretics include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE DRUG NAMES OF POTASSIUM-SPARING DIURETICS?

Generic and brand names of potassium-sparing diuretics drugs include:

References
https://reference.medscape.com/drugs/diuretics-potassium-sparing

https://pubmed.ncbi.nlm.nih.gov/2455308/

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