How Do Renin Inhibitors Combos Work?

Reviewed on 11/19/2021

HOW DO RENIN INHIBITORS COMBOS WORK?

Renin-inhibitors combos are a class of drugs used for the treatment of hypertension (high blood pressure). Lowering high blood pressure helps in preventing cardiovascular events such as strokes (blockage in the blood supply to the brain) and myocardial infarctions (heart attacks), and kidney diseases.

Renin-inhibitors combos are a combination of two or three medicines that work together to lower blood pressure. 

  • Aliskiren (a direct renin inhibitor): It affects the renin-angiotensin-aldosterone system by inhibiting proteolytic enzyme “renin” released by the kidneys and prevents renin from converting angiotensin to angiotensin I which is then converted to angiotensin II (a vasoconstrictor that causes high blood pressure). This inhibition of angiotensin II helps in the relaxation and widening of blood vessels and maintenance of proper blood flow.
  • Hydrochlorothiazide (a thiazide diuretic or water pill): It reduces blood volume by inhibiting the sodium-chloride cotransporter in the kidneys, preventing sodium reabsorption, and inducing water excretion in the form of excess urine
  • Amlodipine (a calcium channel blocker): It works by inhibiting calcium ion influx across cell membranes, with a greater effect on vascular smooth muscle cells that causes vasodilation (relaxing or widening the blood vessels) and a reduction in peripheral vascular resistance, thus lowering blood pressure and improving the blood flow to the heart.

Renin-inhibitors combos are administered via the oral route, typically once a day with or without food.

SLIDESHOW

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HOW ARE RENIN INHIBITORS COMBOS USED?

Renin inhibitors combos are indicated for the treatment of hypertension in adults:

  • When one medicine to lower high blood pressure is not enough
  • As the initial medicine to lower high blood pressure if the physician decides that more than one medicine is required

WHAT ARE SIDE EFFECTS OF RENIN INHIBITORS COMBOS?

Side effects associated with renin inhibitor combos include:

Other rare side effects include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF RENIN INHIBITORS COMBOS?

Generic and brand names of renin inhibitors combos include:

References
https://reference.medscape.com/drugs/renin-inhibitors-combos

https://www.webmd.com/drugs/2/drug-149962/aliskiren-hydrochlorothiazide-oral/details

https://www.rxlist.com/tekturna-hct-drug.htm

https://www.rxlist.com/amturnide-drug.htm#description

https://www.webmd.com/drugs/2/drug-149976/tekturna-hct-oral/details

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754847/

https://www.medicinenet.com/tekturna_hct_hydrochlorothiazide_and_aliskiren/article.htm

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