How Do Second-generation Cephalosporins Work?

Reviewed on 5/10/2021

How Do Second-generation Cephalosporins Work?

Cephalosporins are broad-spectrum antibiotics used to manage a wide range of bacterial infections. They are derived from the mold Acremonium (previously called Cephalosporium). Cephalosporins are grouped into five generations based on their spectrum of coverage against gram-positive and gram-negative bacteria.

Second-generation cephalosporins act on both gram-positive and gram-negative bacteria. However, they are relatively less effective against gram-positive bacteria and more effective against gram-negative bacteria than first-generation cephalosporins.

They inhibit bacterial cell wall synthesis. The bacterial cell wall contains peptidoglycan units that increase the strength of the cell wall by cross-linking with each other through penicillin-binding proteins. Cephalosporins have beta-lactam rings that bind to the penicillin-binding protein and inhibit the cross-linking of peptidoglycans. Because of this action, the cell wall is compromised resulting in the lysis (rupture of the cell wall) and death of the bacterial cell.

Second-generation cephalosporins are divided into two subgroups:

  • Second-generation subgroups include cefuroxime and cefprozil. Cefuroxime has increased coverage against H influenza.
  • Cephamycin subgroup has increased coverage against bacteroides species

How Are Second-generation Cephalosporins Used?

Second-generation cephalosporins are used to treat:

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What Are Side Effects of Second-generation Cephalosporins?

Most of the minor side effects occur only once at the initiation of therapy and resolve within 1 to 2 days.

The common side effects include:

Rare but serious side effects may include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What Are Names of Second-generation Cephalosporins Drugs?

Names of second-generation cephalosporins include:

References
https://reference.medscape.com/drugs/cephalosporins-2nd-generation

https://www.ncbi.nlm.nih.gov/books/NBK551517/

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