How Do Selective Beta-1-Blockers Work?

Reviewed on 6/8/2021

WHAT ARE SELECTIVE BETA-1 BLOCKERS AND HOW DO THEY WORK?

Selective beta-1 blockers are a subclass of beta-blockers that are commonly used to treat high blood pressure.

Beta-1 receptors are mainly found in the cardiac tissues and kidneys. Selective beta-1-blockers bind to the beta-1 receptor sites and inhibit the action of hormones norepinephrine and epinephrine. Norepinephrine and epinephrine are the hormones that are produced by the adrenal gland and also by the nerve cells and are released inside the circulatory system when a person is emotionally stressed.  

Beta-1 receptors upon activation, increase the intracellular calcium concentration in heart muscles, leading to increased heart muscle contractions and heart rate. The enzyme renin is released into the circulation by the kidneys when the smooth muscles are activated and this triggers the production of sodium and water regulatory hormones, angiotensin II and aldosterone. These hormones cause retention of sodium and water and increase blood pressure.

HOW ARE SELECTIVE BETA-1 BLOCKERS USED?

In addition to high blood pressure, selective beta-1 blockers are used in conditions such as:

WHAT ARE SIDE EFFECTS OF SELECTIVE BETA-1 BLOCKERS?

Common side effects of selective beta-1 blockers include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

SLIDESHOW

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WHAT ARE DRUG NAMES OF SELECTIVE BETA-1 BLOCKERS?

Drug names include:

References
https://reference.medscape.com/drugs/beta-blockers-beta-1-selective

https://www.cochrane.org/CD007451/HTN_beta-1-selective-blockers-treatment-high-blood-pressure

https://www.ncbi.nlm.nih.gov/books/NBK499982/#:~:text=The%20cardio%2Dselective%20beta%2D1,acebutolol%2C%20metoprolol%2C%20and%20nebivolol.

https://www.rxlist.com/beta_blockers/drug-class.htm

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