How Do SNDRI Antidepressants Work?

Reviewed on 9/22/2021

How do SNDRI antidepressants work?

Serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) antidepressants are medications that are being developed to treat depression. Ansofaxine, a novel SNDRI, is in clinical trials for safety and efficacy for the treatment of the major depressive disorder.

SNDRIs are believed to improve mood by increasing the levels of serotonin, norepinephrine, and dopamine, which are chemicals (neurotransmitters) released by nerve cells (neurons) in the brain

Neurotransmitters enable the transmission of nerve signals and regulate physiological functions such as breathing, heart rate, and digestion, and are also responsible for learning, memory, sleep, emotions, and behavior. 

SNDRIs increase the levels of serotonin, norepinephrine, and dopamine by inhibiting their reabsorption (reuptake), a natural process in the brain after the transmission of neural signals. 

How are SNDRI antidepressants used?

Information on formulations and administration of SNDRI antidepressants is not available at present. SNDRI is a new drug in clinical trials, pending approval by the FDA for the treatment of the major depressive disorder.

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What are side effects of SNDRI antidepressants?

Currently, no information is available on the side effects of SNDRI antidepressants. Early studies, however, indicate that SNDRIs may be able to mitigate some of the side effects of conventional antidepressants such as SSRIs and SNRIs.

Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) increase levels of serotonin and norepinephrine, which are responsible for many of the body’s functions.

SNDRIs, in addition, increase the levels of dopamine, which regulates memory, learning, and pleasant sensation, and consequently, may be able to reduce some side effects of SSRIs and SNRIs such as anhedonia (inability to feel pleasure) and sexual dysfunction, and improve cognition.

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What are names of some SNDRI antidepressant drugs?

Generic name of the SNDRI antidepressant drug currently in clinical trials is:

  • ansofaxine (pending FDA approval)
References
https://reference.medscape.com/drugs/antidepressants-sndris

https://www.researchgate.net/publication/346871102_Ansofaxine_Hydrochloride

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