How Do Sphingosine 1-phosphate Receptor Modulators Work?

Reviewed on 11/22/2021

HOW DO SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS WORK?

Sphingosine 1-phosphate (S1P) receptor modulators are a class of drugs used to treat and prevent the worsening of disability in adults with relapsing-remitting forms (course of disease where symptoms flare up from time to time) of multiple sclerosis

Multiple sclerosis is a chronic, devastating inflammatory disease of the brain, spinal cord, and optic nerves that often progresses and causes severe neurological, physical, and cognitive effects. Signs and symptoms of multiple sclerosis include:

S1P receptor modulators are immunomodulatory medications that prevent the immune cells (lymphocytes) from attacking the nerves in the brain and the spinal cord. They selectively bind to various S1P receptors (1, 3, 4, and 5) found on lymphocytes and suppresses the migration of lymphocytes from lymph nodes to the location of the inflammation, leading to a lower level of lymphocytes circulating in the peripheral circulation and thus preventing the damage caused to the nerves.

The inhibitors of S1P receptor modulators are administered via the oral route, typically once a day with or without food.

HOW ARE SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS USED?

S1P receptor modulators are indicated for:

QUESTION

What kind of disease is multiple sclerosis? See Answer

WHAT ARE SIDE EFFECTS OF SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS?

Some of the common side effects include:

Other rare side effects include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS?

Generic and brand names of S1P receptor modulators include:

References
https://reference.medscape.com/drug/mayzent-siponimod-1000302

https://reference.medscape.com/drug/gilenya-fingolimod-999602

https://reference.medscape.com/drug/zeposia-ozanimod-1000358

https://medlineplus.gov/druginfo/meds/a619027.html

https://www.webmd.com/drugs/2/drug-177040/siponimod-oral/details\

https://medlineplus.gov/druginfo/meds/a611006.html

https://www.webmd.com/drugs/2/drug-154675/fingolimod-oral/details

https://medlineplus.gov/druginfo/meds/a620029.html

https://www.rxlist.com/gilenya-drug.htm

https://emedicine.medscape.com/article/1146199-medication#5

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