How Do Sulfonamides Work?

Reviewed on 10/22/2021

How Do Sulfonamides Work?

Sulfonamides or sulfa drugs are a class of antibiotics that target bacteria causing infections. These classes of drugs are generally broad-spectrum antibiotics that act on a wide range of bacterial types and are therefore employed in treating many kinds of bacterial infections. Sulphonamides do not kill bacteria, but it interferes with the ability of bacteria to grow and multiply (bacteriostatic).

Folic acid is a key component of bacteria that it uses for growth and multiplication. Sulfa drugs block the ability of the bacteria to use folic acid, thereby inhibiting the growth process. As a result, the bacteria fail to reproduce and spread. Because humans do not make folic acid and completely rely on diet for getting their folic acid, they remain safe against the adverse effects of inhibition of folate production.

Sometimes, sulfa drugs are given in combination with trimethoprim because it kills the bacteria (bactericidal). Hence, the combination of sulfonamides and trimethoprim stops the bacteria from multiplying and kills them as well.

How Are Sulfonamides Used?

Sulfonamides are mainly used to treat bacterial infections and some fungal infections. As they tend to concentrate more in the urine, they are most effective against urinary tract infections.

What Are Side Effects of Sulfonamides?

Some of the side effects of sulfonamides include:

Rare side effects include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.


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What Are Names of Sulfonamide Drugs?

Names of Sulfonamides include:

Medscape. Sulphonamides.

MedicineNet. Sulfonamides.

NCBI. Sulfonamides.

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