How Do Thiazide Diuretics Work?

Reviewed on 6/14/2021

WHAT ARE THIAZIDE DIURETICS AND HOW DO THEY WORK?

Diuretics also known as water pills are a class of drugs that cause diuresis (increased production of urine by the kidneys). Diuretics are drugs that work on the kidneys to remove electrolytes such as sodium and chloride from the body in the urine. These electrolytes draw water along with them; thus, excess water also gets eliminated in the urine. They are used to treat conditions associated with the presence of excess sodium and water in the body such as hypertension and fluid overload in the body that may damage major organs such as the heart and cause edema (accumulation of fluid in the body tissues causing swelling, usually seen due to damage to the small vessels).

Thiazide diuretics are drugs that cause both natriuresis (removal of sodium in the urine) and diuresis. Thiazide diuretics work by blocking sodium and chloride (Na/Cl) channels in the distal convoluted tubule of the nephron and inhibit the reabsorption of sodium and water. This also causes a loss of potassium and calcium ions.

HOW ARE THIAZIDE DIURETICS USED?

Thiazide diuretics are taken orally and used in conditions such as:

WHAT ARE SIDE EFFECTS OF THIAZIDE DIURETICS?

The side effects associated with thiazide diuretics include:

Rare but serious side effects of thiazide diuretics may include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

QUESTION

Salt and sodium are the same. See Answer

WHAT ARE DRUG NAMES OF THIAZIDE DIURETICS?

Generic and brand names of thiazide diuretics drugs include:

References
https://reference.medscape.com/drugs/diuretics-thiazide

https://www.ncbi.nlm.nih.gov/books/NBK532918/

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