How Do Third-generation Cephalosporins Work?

Reviewed on 5/10/2021

How Do Third-generation Cephalosporins Work?

Cephalosporins are broad-spectrum antibiotics used to manage a wide range of bacterial infections. They are derived from the mold Acremonium (previously called Cephalosporium). Cephalosporins are grouped into five generations based on their spectrum of coverage against gram-positive and gram-negative bacteria. They are administered intravenously, intramuscularly, or orally depending on the infection.

Third-generation cephalosporins are more effective against gram-negative bacteria than the first and second generations. They are usually effective against bacteria that may be resistant to previous generations of cephalosporins.

Cephalosporins inhibit bacterial cell wall synthesis. The bacterial cell wall is strengthened by the cross-linking of peptidoglycans with the help of penicillin-binding proteins. Cephalosporins have beta-lactam rings that bind with penicillin-binding proteins and block them. The cross-linking of peptidoglycans is then hampered, and the cell wall is not formed, resulting in the death of the bacterial cell.

How Are Third-generation Cephalosporins Used?

Third-generation cephalosporins are used to treat:

What Are Side Effects of Third-generation Cephalosporins?

Side effects associated with third-generation cephalosporins include:

Serious side effects may include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

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What Are Names of Third-generation Cephalosporins Drugs?

Names of third-generation cephalosporins include:

References
https://reference.medscape.com/drugs/cephalosporins-3rd-generation

https://www.ncbi.nlm.nih.gov/books/NBK551517/

https://www.msdmanuals.com/en-in/professional/infectious-diseases/bacteria-and-antibacterial-drugs/cephalosporins

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