How Do Thrombopoietic Agents Work?

Reviewed on 8/10/2021

HOW DO THROMBOPOIETIC AGENTS WORK?

Thrombopoietic agents also known as thrombopoiesis-stimulating agents (thrombopoiesis is the formation of platelets in the bone marrow) are recombinant forms of human thrombopoietin (TPO), a hematopoietic growth factor that regulates thrombocytosis (high platelet count) and are used to treat thrombocytopenia (low platelet count) because of chemotherapychronic liver disease, and myelodysplastic syndromes. 

TPO is an endogenous ligand that binds to TPO receptors present on megakaryocyte precursors, megakaryocytes, and platelets. This promotes the proliferation of  megakaryocytic cells and increases platelets production.

The therapeutic use of human TPO may provoke an immune response, leading to the development of neutralizing anti-TPO antibodies. Recombinant forms were developed to prevent immunogenicity. They act as TPO receptor agonists and mimic the platelet-promoting action of human TPO.

HOW ARE THROMBOPOIETIC AGENTS USED?

Thrombopoietic agents are used to treat:

WHAT ARE SIDE EFFECTS OF THROMBOPOIETIC AGENTS?

Side effects of thrombopoietic agents may include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF THROMBOPOIETIC AGENTS?

Generic and brand names of thrombopoietic agents include:

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References
https://reference.medscape.com/drugs/thrombopoietic-agents

https://pubmed.ncbi.nlm.nih.gov/18457458/

https://ashpublications.org/hematology/article/2007/1/106/19165/Novel-Thrombopoietic-Agents

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