How Do Topical Anticholinergics Work?

Reviewed on 6/18/2021

HOW DO TOPICAL ANTICHOLINERGICS WORK?

Topical anticholinergics are a class of medications used to treat hyperhidrosis. Hyperhidrosis is abnormally excessive sweating not necessarily related to heat or exercise; it can cause discomfort and embarrassment, and the people affected may have trouble working or enjoying recreational activities that negatively affect the quality of life.

Topical anticholinergics are administered as a drug solution on a premoistened cloth for application to the skin. They work in the following ways:

  • They block the action of a neurotransmitter called “acetylcholine” in the central and peripheral nervous systems.
  • Acetylcholine is responsible for transferring signals between certain cells that perform specific bodily functions (including digestion, urination, salivation).
  • Topical anticholinergics block the activation of muscarinic acetylcholine receptors in the peripheral sweat glands, which reduces sweat production.

HOW ARE TOPICAL ANTICHOLINERGICS USED?

  • Topical anticholinergics are used for treating hyperhidrosis.

WHAT ARE SIDE EFFECTS OF TOPICAL ANTICHOLINERGICS?

Common side effects include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

QUESTION

Sweat is odorless. See Answer

WHAT ARE NAMES OF TOPICAL ANTICHOLINERGICS?

Drug names include:                              

  • Glycopyrronium tosylate topical
  • Qbrexza
References
https://reference.medscape.com/drugs/anticholinergics-topical

https://dermnetnz.org/topics/anticholinergic-medications/

https://www.webmd.com/drugs/2/drug-175650/glycopyrronium-tosylate-topical/details

https://www.rxlist.com/qbrexza-drug.htm#description

Health Solutions From Our Sponsors