How Do Uricosuric Agents Work?

Reviewed on 1/21/2022

How do uricosuric agents work?

Uricosuric agents are medications prescribed for the treatment of gout, a painful arthritic condition caused by excessive uric acid in the blood that gets deposited as monosodium urate crystals in joints. Gout most commonly affects the big toes, but can also affect other joints such as ankles, knees, elbows, wrists, and fingers.

Uricosuric agents work in the following ways to prevent joint inflammation caused by gout:

Uricosuric agents are also used as an adjunct treatment in some bacterial infections because they inhibit the secretion of certain antibiotics such as penicillin and cephalosporins by the kidneys and prolong their bioavailability.

How are uricosuric agents used?

Uricosuric agents are oral tablets approved by the FDA for use in the following conditions:

QUESTION

Gout is a form of arthritis. See Answer

What are side effects of uricosuric agents?

Side effects of uricosuric agents may include the following:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What are names of some uricosuric agents?

Generic and brand names of uricosuric agents include:

  • colchicine/probenecid
  • Col-probenecid
  • probenecid
  • Probalan
References
https://reference.medscape.com/drugs/uricosuric-agents

https://www.hhs.texas.gov/sites/default/files/documents/about-hhs/communications-events/meetings-events/dur/apr-2021-durb-agenda-item3g.pdf

https://pubchem.ncbi.nlm.nih.gov/compound/Probenecid#section=Pharmacology-and-Biochemistry

https://www.clinicaltherapeutics.com/article/S0149-2918(14)00457-3/fulltext

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