How Do Urinary Analgesics Work?

How do urinary analgesics work?

Urinary analgesics are medications to relieve pain and irritation in the urinary tract and the bladder. Two types of medications are used as urinary analgesics:

  • Phenazopyridine: Phenazopyridine is an over-the-counter azo dye medication that works as a painkiller by soothing the lining of the urinary tract. Phenazopyridine does not treat the cause of urinary irritation but can relieve symptoms until other treatments start working.
  • Pentosan polysulfate sodium: Pentosan polysulfate sodium is a polysaccharide (carbohydrate) and a weak anticoagulant medication, prescribed to treat bladder pain. Pentosan polysulfate sodium is thought to adhere to the mucous membrane (mucosa) of the bladder wall and protect the tissue from irritating substances in the urine.

How are urinary analgesics used?

Urinary analgesics are administered as tablets or capsules to treat urinary tract and bladder pain from conditions such as:

  • Dysuria (pain or burning during urination)
  • Irritation of lower urinary tract mucosa
  • Interstitial cystitis, a painful bladder condition that causes frequent and urgent urination

Pentosan polysulfate sodium also has orphan use designation in the treatment of:

  • Sickle cell disease: Sickle cell disease is a condition in which red blood cells become misshapen and sickle-shaped, break down early, and can block blood flow. The anticoagulant properties of pentosan polysulfate sodium can help improve blood flow.
  • Mucopolysaccharidosis type IV: Mucopolysaccharidosis is a rare hereditary disorder in which the body is unable to properly break down mucopolysaccharides (chain of sugar molecules), also known as glycosaminoglycans (GAG). Consequently, GAG builds up and disrupts cellular functions. Pentosan polysulfate protects the bladder mucosa from GAG in urine.

What are side effects of urinary analgesics?

Side effects of urinary analgesics may include the following:


Pentosan polysulfate sodium

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What are names of some urinary analgesic drugs?

Generic and brand names of urinary analgesic drugs include:

  • Azo Standard
  • Baridium
  • Elmiron
  • pentosan polysulfate sodium
  • phenazopyridine
  • Prodium
  • Pyridiate
  • Pyridium
  • Uricalm
  • Urodine
  • UTI Relief

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