How Do VZV Antivirals Work?

Reviewed on 10/22/2021

HOW DO VZV ANTIVIRALS WORK?

Varicella-Zoster virus (VZV) antivirals are used in the treatment of both varicella and zoster infections. VZV is also called human herpesvirus 3. The replication of VZV in infected cells can be blocked effectively by the administration of antiviral agents. VZV antiviral drugs get incorporated into viral DNA preventing further synthesis and viral replication.

The primary infection of VZV is varicella commonly known as chickenpox, and the reactivation of VZV - causes zoster or herpes zoster commonly known as shingles. VZV is highly contagious and transmitted predominantly by airborne droplet infection.

Acyclovir is active against most herpes viruses and is the standard therapeutic agent for the treatment of VZV infections. Acyclovir is converted into acyclovir monophosphate by the viral thymidine kinase enzyme, which is then converted into acyclovir triphosphate (ACV-TP) by the host cell kinases. The formed ACV-TP competitively inhibits and inactivates virus DNA polymerase and prevents viral DNA synthesis and virus replication.

HOW ARE VZV ANTIVIRALS USED?

VZV antivirals are used to treat varicella and zoster caused by VZV.

QUESTION

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WHAT ARE SIDE EFFECTS OF VZV ANTIVIRALS?

Side effects of VZV antivirals may include:

Rare but serious side effects of VZV antivirals may include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF VZV ANTIVIRALS?

Generic and brand names of VZV antiviral include:

References
https://reference.medscape.com/drugs/antivirals-vzv

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301744/#:~:text=in%20clinical%20use-,Acyclovir,zoster%20disease%20in%20immunocompetent%20patients.

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