How Does Nitric Oxide Gas Work?

Reviewed on 12/29/2021

How does nitric oxide gas work?

Nitric oxide gas is used for treating respiratory failure in newborns caused by low tissue saturation of oxygen (hypoxia). Nitric oxide gas improves blood flow and oxygen levels in the pulmonary arteries by relaxing the smooth muscles around pulmonary blood vessels, which dilates them and reduces pulmonary hypertension.

Nitric oxide gas molecules bind to soluble guanylate cyclase (sGC), an enzyme in the cardiopulmonary system, and activate the synthesis of a signaling molecule known as cyclic guanosine monophosphate (cGMP). An increase in cGMP concentration leads to relaxation of the pulmonary vascular smooth muscles.

How is nitric oxide gas used?

Nitric oxide gas is administered through the ventilator using a calibrated nitric oxide delivery system and is approved by FDA for the treatment of hypoxic respiratory failure in newborns. Nitric oxide gas is also being developed for use in other conditions and has orphan designation for the following:

Pediatric

Adults

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What are side effects of nitric oxide gas?

Side effects of nitric oxide gas may include the following:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What are names of some nitric oxide gas products?

Generic and brand names of nitric oxide gas products include:

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