How Does Ziconotide Work?

Reviewed on 9/22/2021

How does ziconotide work?

Ziconotide is a non-opioid analgesic that is prescribed to treat chronic pain that is not relieved by alternate medications. Ziconotide prevents the transmission of pain through the spine by the blocking conduction of pain signals by the nerve cells (neurons).

Ziconotide blocks calcium channels on the surface of neurons and prevents the inflow of calcium ions into the neurons. Blocking calcium channels prevents the release of chemicals (neurotransmitters) that transmit pain signals. Ziconotide is not addictive, being a non-opioid analgesic.

How is ziconotide used?

Ziconotide is administered as an injection into the spinal canal (intrathecal) and is used to treat chronic pain.

What are side effects of ziconotide?

Side effects of ziconotide may include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What are names of some ziconotide drugs?

Generic and brand names of ziconotide include:


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