Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 9/26/2022

Drug Summary

What Is Humatin?

Humatin (paromomycin sulfate) is a broad spectrum antibiotic indicated for intestinal amebiasis – acute and chronic (NOTE: Humatin is not effective in extraintestinal amebiasis), and as adjunctive therapy in management of hepatic coma.

What Are Side Effects of Humatin?

Humatin may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • diarrhea that is watery or bloody, and
  • worsening symptoms

Get medical help right away, if you have any of the symptoms listed above.

Common side effects of Humatin include:

  • nausea
  • abdominal cramps
  • diarrhea

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Humatin

The dose of Humatin to treat intestinal amebiasis in adults and pediatric patients is 25 to 35 mg/kg body weight daily, administered in three doses with meals, for five to ten days. The adult dose of Humatin to manage hepatic coma is 4 g daily in divided doses, given at regular intervals for five to six days.

What Drugs, Substances, or Supplements Interact with Humatin?

Humatin may interact with other drugs.

Humatin During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or breastfeeding before taking Humatin.

Additional Information

Our Humatin (paromomycin sulfate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

Drug Description


Humatin is a broad spectrum antibiotic produced by Streptomyces rimosus var. paromomycinus . It is a white, amorphous, stable, water-soluble product supplied as capsules containing the equivalent of 250 mg paromomycin.

The capsule contains D&C yellow No. 10; FD&C blue No. 1; FD&C red No. 3; FD&C yellow No. 6; gelatin, NF; and titanium dioxide, USP.

Indications & Dosage


Paromomycin sulfate is indicated for intestinal amebiasis–acute and chronic (NOTE-It is not effective in extraintestinal amebiasis); management of hepatic coma–as adjunctive therapy.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of HUMATIN™ Capsules and other antibacterial drugs, HUMATIN™ Capsules should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.


Intestinal Amebiasis

Adults and Pediatric Patients: Usual dose - 25 to 35 mg/kg body weight daily, administered in three doses with meals, for five to ten days.

Management Of Hepatic Coma


Usual dose - 4 g daily in divided doses, given at regular intervals for five to six days.


HUMATIN™ Capsules each contain paromomycin sulfate equivalent to 250 mg paromomycin, are supplied as follows:

NDC 80725-250-01: Bottles of 100

The capsule is Dark Blue Opaque /White Opaque, imprinted with "HP 38" in black ink on the cap and on the body.


Store at 20°-25°C (68°-77°F) [See USP controlled Room Temperature] Protect from moisture.

Preserve in tight containers as defined in the USP.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

MANUFACTURED FOR: Waylis Therapeutics LLC, Wixom, MI 48393. Revised: Jan 2021.

Side Effects & Drug Interactions


Nausea, abdominal cramps, and diarrhea have been reported in patients on doses over 3 g daily.

To report SUSPECTED ADVERSE REACTIONS, Waylis Therapeutics LLC at 844-200-7910 or FDA at 1- 800-FDA-1088 or


No Information Provided

Warnings & Precautions


No Information Provided


Prescribing HUMATIN™ Capsules in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug resistant bacteria.

The use of this antibiotic, as with other antibiotics, may result in an overgrowth of nonsusceptible organisms, including fungi. Constant observation of the patient is essential. If new infections caused by nonsusceptible organisms appear during therapy, appropriate measures should be taken. The drug should be used with caution in individuals with ulcerative lesions of the bowel to avoid renal toxicity through inadvertent absorption.

Pediatric Use


Overdose & Contraindications


No Information Provided


Paromomycin sulfate is contraindicated in individuals with a history of previous hypersensitivity reactions to it. It is also contraindicated in intestinal obstruction.

Clinical Pharmacology


The in-vitro and in-vivo antibacterial action of paromomycin closely parallels that of neomycin. It is poorly absorbed after oral administration, with almost 100% of the drug recoverable in the stool.

Medication Guide


Patients should be counseled that antibacterial drugs including HUMATIN™ Capsules should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When HUMATIN™ Capsules is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by HUMATIN™ Capsules or other antibacterial drugs in the future.

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.