Humira vs. Duobrii

Are Humira and Duobrii the Same Thing?

Humira (adalimumab) and Duobrii (halobetasol propionate and tazarotene) Lotion are used to treat plaque psoriasis.

Humira is also used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, and ankylosing spondylitis. Humira is also used to treat Crohn's disease after other drugs have been tried without successful treatment of symptoms.

Humira and Duobrii belong to different drug classes. Humira is a monoclonal antibody and Duobrii is a combination of a corticosteroid and a retinoid.

Humira is injected under the skin and Duobrii is a topical (for the skin) medication.

Side effects of Humira that are different from Duobrii include injection site reactions (redness, itching, pain, bruising, swelling, or bleeding), headache, stuffy nose, sinus pain, and stomach pain.

Side effects of Duobrii that are different from Humira include contact dermatitis, application site pain, infected hair follicles, thinning skin, skin abrasions, rash, stretch marks, and skin peeling.

Humira may interact with abatacept, etanercept, anakinra, azathioprine, mercaptopurine, monoclonal antibodies, and live vaccines such as measles/mumps/rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Duobrii may interact with corticosteroids taken by mouth or injection, or other products used on your skin that contain corticosteroids.

What Are Possible Side Effects of Humira?

Common side effects of Humira include:

  • injection site reactions (redness, itching, pain, bruising, swelling, or bleeding),
  • headache,
  • suffy nose,
  • sinus pain, or
  • stomach pain.

Tell your doctor if you have serious side effects of Humira including:

  • fast/irregular/pounding heartbeat,
  • stomach pain,
  • blood in the stools,
  • mental/mood changes,
  • severe headache,
  • easy bruising or bleeding,
  • dark urine,
  • yellowing eyes and skin,
  • leg pain or swelling,
  • numbness or tingling of the arms/hands/legs/feet,
  • unsteadiness,
  • unexplained muscle weakness,
  • difficulty with speaking/chewing/swallowing/facial movements,
  • vision changes,
  • extreme fatigue,
  • joint pain, or
  • butterfly-shaped rash on the nose and cheeks.

What Are Possible Side Effects of Duobrii?

Common side effects of Duobrii include:

  • contact dermatitis,
  • application site pain,
  • infected hair follicles,
  • thinning skin,
  • skin abrasions,
  • rash,
  • stretch marks, and
  • skin peeling

What Is Humira?

Humira (adalimumab) is an injectable protein (antibody) used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. Humira is also used to treat Crohn's disease after other drugs have been tried without successful treatment of symptoms.

What Is Duobrii?

Duobrii (halobetasol propionate and tazarotene) Lotion is a combination of a corticosteroid and a retinoid indicated for the topical treatment of plaque psoriasis in adults.

QUESTION

Psoriasis causes the top layer of skin cells to become inflamed and grow too quickly and flake off. See Answer

What Drugs Interact With Humira?

Humira may interact with azathioprine or mercaptopurine. Asacol may also interact with pentamidine, tacrolimus, amphotericin B, antibiotics, antiviral medicines, cancer medicine, or aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs).

Humira may also interact with abatacept, anakinra, infliximab, etanercept, certolizumab pegol, golimumab, or rituximab.

What Drugs Interact With Duobrii?

Duobrii Lotion may interact with corticosteroids taken by mouth or injection, or other products used on your skin that contain corticosteroids. Tell your doctor all medications and supplements you use. Duobrii Lotion is not recommended for use during pregnancy; it may harm a fetus. A negative result for pregnancy should be obtained within 2 weeks prior to Duobrii Lotion therapy, which should begin during menstruation. Females of reproductive potential are advised to use effective contraception during treatment with Duobrii Lotion. It is unknown if Duobrii passes into breast milk.

How Should Humira Be Taken?

Humira is given by an injection under the skin. Your doctor will tell you how often to take an injection of Humira. This is based on your condition to be treated. Do not inject Humira more often than you were prescribed.

Do not try to inject Humira yourself until you have been shown the right way to give the injections. If your doctor decides that you or a caregiver may be able to give your injections of Humira at home, you should receive training on the right way to prepare and inject Humira.

Do not miss any doses of Humira unless your doctor says it is okay. If you forget to take Humira, inject a dose as soon as you remember. Then, take your next dose at your regular scheduled time. This will put you back on schedule.

In case you are not sure when to inject Humira, call your doctor or pharmacist.

If you take more Humira than you were told to take, call your doctor.

How Should Duobrii Be Taken?

Apply a thin layer dose of Duobrii Lotion to the affected areas once daily.

SLIDESHOW

Types of Psoriasis: Medical Pictures and Treatments See Slideshow
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References


Abbvie. Humira Product Monograph.

https://www.humira.com/

FDA. Duobrii Product Information

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/209354s000lbl.pdf

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