Humulin N

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 10/11/2021
Humulin N Side Effects Center

What Is Humulin N?

Humulin N (insulin human recombinant) [Human insulin (rDNA origin) isophane suspension] is a man-made insulin product indicated for glucose control in patients with diabetes. Hypoglycemia (low blood sugar) is a frequent side effect of Humulin N (insulin). Symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, trouble concentrating, confusion, or seizure (convulsions). Other side effects of Humulin N include injection site reactions (pain, redness, irritation). Tell your doctor if you have serious side effects of Humulin including signs of low potassium level in the blood (such as muscle cramps, weakness, irregular heartbeat).

Humulin N (insulin human recombinant) is administered by injection. Any change of insulin should be made cautiously and only under medical supervision. Changes in strength, manufacturer, type (e.g, regular, NPH, analog), species, or method of manufacture may result in the need to change dosage. Humulin N may interact with albuterol, clonidine, reserpine, guanethidine, or beta-blockers. Tell your doctor all medications and supplements you use. Humulin N (insulin human recombinant) should be used during pregnancy only if clearly needed. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is unknown if Humulin N passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Our Humulin N Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Diabetes: What Raises and Lowers Your Blood Sugar Level? See Slideshow
Humulin N Consumer Information

3 pharmacies near 20147 have coupons for HumuLIN N (Brand Names:Humulin N for 10ML of 100UNIT/ML)


Est. Regular Price


with free coupon

View Coupon

Est. Regular Price


with free coupon

View Coupon

Get emergency medical help if you have signs of insulin allergy: redness or swelling where an injection was given, itchy skin rash over the entire body, trouble breathing, chest tightness, feeling like you might pass out, or swelling in your tongue or throat.

Call your doctor at once if you have:

  • fluid retention--weight gain, swelling in your hands or feet, feeling short of breath; or
  • low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Common side effects may include:

  • low blood sugar;
  • weight gain, swelling in your hands or feet;
  • itching, mild skin rash; or
  • thickening or hollowing of the skin where you injected the medicine.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Humulin N (Insulin (Human Recombinant))


Diabetes is defined best as... See Answer
Humulin N Professional Information


The following adverse reactions are discussed elsewhere in the labeling:

The following additional adverse reactions have been identified during post-approval use of HUMULIN N. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or to establish a causal relationship to drug exposure.

Allergic Reactions

Some patients taking HUMULIN N have experienced erythema, local edema, and pruritus at the site of injection. These conditions were usually self-limiting. Severe cases of generalized allergy (anaphylaxis) have been reported [see WARNINGS AND PRECAUTIONS].

Peripheral Edema

Some patients taking HUMULIN N have experienced sodium retention and edema, particularly if previously poor metabolic control is improved by intensified insulin therapy.


Administration of insulin subcutaneously, including HUMULIN N, has resulted in lipoatrophy (depression in the skin) or lipohypertrophy (enlargement or thickening of tissue) [see DOSAGE AND ADMINISTRATION] in some patients.

Weight gain

Weight gain has occurred with some insulin therapies including HUMULIN N and has been attributed to the anabolic effects of insulin and the decrease in glycosuria.


Development of antibodies that react with human insulin have been observed with all insulin, including HUMULIN N.

Read the entire FDA prescribing information for Humulin N (Insulin (Human Recombinant))

© Humulin N Patient Information is supplied by Cerner Multum, Inc. and Humulin N Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors