Humulin R vs. Humalog

Reviewed on 1/28/2021

Are Humulin R and Humalog the Same Thing?

Humulin R (insulin [human recombinant]) and Humalog (insulin lispro injection) are forms of insulin indicated as adjuncts to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus.

Humulin R is a form of short-acting insulin and Humalog is a rapid-acting human insulin analog.

Side effects of Humulin R and Humalog that are similar include low blood sugar (hypoglycemia) (symptoms include headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, and seizures [severe hypoglycemia can be fatal]) and injection site reactions (e.g., pain, redness, irritation).

Both Humulin R and Humalog may interact with clonidine, reserpine, guanethidine, and beta-blockers.

Humulin R may also interact with albuterol.

Humalog may also interact with antidiabetic agents, salicylates, sulfonamide antibiotics, monoamine oxidase inhibitors, fluoxetine, pramlintide, disopyramide, fibrates, propoxyphene, pentoxifylline, ACE inhibitors, angiotensin II receptor blocking agents, somatostatin analogs, corticosteroids, isoniazid, niacin, estrogens, oral contraceptives, phenothiazines, danazol, diuretics, sympathomimetic agents, somatropin, atypical antipsychotics, glucagon, protease inhibitors, thyroid hormones, lithium salts, alcohol, and pentamidine.

What Are Possible Side Effects of Humulin R?

Common side effects of Humulin R include:

  • injection site reactions (e.g., pain, redness, irritation).

Low blood sugar (hypoglycemia) is the most common side effect of Humulin R.

Symptoms of low blood sugar include:

  • headache,
  • hunger,
  • weakness,
  • sweating,
  • tremors,
  • irritability,
  • trouble concentrating,
  • rapid breathing,
  • fast heartbeat,
  • fainting, or
  • seizure (severe hypoglycemia can be fatal).

Tell your doctor if you have serious side effects of Humulin R including:

What Are Possible Side Effects of Humalog?

Common side effects of Humalog include:

  • injection site reactions (e.g., pain, redness, irritation).
  • Low blood sugar (hypoglycemia), is the most common side effect of insulin lispro such as Humalog.
  • Symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, trouble concentrating, confusions, or seizure (convulsions).
  • Low blood potassium levels (hypokalemia). Symptoms include dry mouth, increased thirst, increased urination, uneven heartbeats, muscle pain or weakness, leg pain or discomfort, or confusion

SLIDESHOW

Diabetes: What Raises and Lowers Your Blood Sugar Level? See Slideshow

What Is Humulin R?

Humulin R (insulin (human recombinant)) is a hormone that is produced in the body used to treat diabetes.

What Is Humalog?

Humalog (insulin lispro [rDNA origin]) Injection is a hormone that is produced in the body used to treat type 1 (insulin-dependent) diabetes in adults. Humalog is usually given together with another long-acting insulin. Humalog is also used together with oral medications to treat type 2 (non insulin-dependent) diabetes in adults.

What Drugs Interact With Humulin R?

Humulin R may interact with albuterol, clonidine, reserpine, guanethidine, or beta-blockers. Tell your doctor all medications you are taking.

What Drugs Interact With Humalog?

Humalog may interact with albuterol, clonidine, reserpine, guanethidine, or beta-blockers. Many other medicines can increase or decrease the effects of insulin lispro on lowering blood sugar. Tell your doctor all prescription and over-the-counter medications and supplements you use.

How Should Humulin R be Taken?

The recommended starting dose of Humulin R for patients 6 years and older is 25 mg once daily in the morning. The dosage of Humulin R may be increased in increments of 10 to 15 mg at intervals of at least 5 days.

How Should Humalog be Taken?

The total daily insulin requirement varies and the dose is usually between 0.5 to 1 unit/kg/day. Insulin needs may be altered during stress, major illness, or changes in exercise, meal patterns, or co-administered drugs.

QUESTION

Diabetes is defined best as... See Answer
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Lilly. Humulin R Product Information.

https://www.humulin.com/insulin-options

Lilly. Humalog Drug Information.

https://www.humalog.com/

Health Solutions From Our Sponsors