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Hyaluronic Acid

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How does Hyaluronic Acid work?

Hyaluronic acid works by acting as a cushion and lubricant in the joints and other tissues. In addition, it might affect the way the body responds to injury and may decrease inflammation.

Are there safety concerns?

Hyaluronic acid is LIKELY SAFE when taken by mouth, applied to the skin, or given by injection and appropriately. Hyaluronic acid can cause redness and soreness when injected into the joint. Rarely, it may cause allergic reactions. Hyaluronic acid can increase eye pressure when injected into the eye. But this usually resolves within 48 to 72 hours.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Hyaluronic acid is POSSIBLY SAFE when given by injection during pregnancy. However, not enough is known about the safety of hyaluronic acid when taken by mouth or applied to the skin during pregnancy. Stay on the safe side and avoid use.

Hyaluronic acid is POSSIBLY UNSAFE when given by injection during breast feeding. Researchers do not know if it affects breast milk and what effect that might have on an infant. There is not enough reliable information about the safety of taking hyaluronic acid by mouth or applying it to the skin if you are breastfeeding. Stay on the safe side and avoid use.

Dosing considerations for Hyaluronic Acid.

The following doses have been studied in scientific research:

BY MOUTH:
  • For aging skin: A specific product (GliSODin Skin Nutrients Advanced Anti-Aging Formula, Isocell North America Inc.) containing krill oil, sea buckthorn berry oil, cacao bean extract, and hyaluronic acid, has been used daily for 90 days.
APPLIED TO THE SKIN:
  • For mouth sores: Hyaluronic acid (Gelclair, Helsinn Healthcare SA) can be mixed with water and used as a mouth rinse.
BY INJECTION:
  • For aging skin: Healthcare providers can inject a hyaluronic acid product (Juvéderm Ultra Plus, Allergan) into skin wrinkles.
BY A CATHETER:
  • Urinary tract infection (UTI): Solution containing 40 mg of hyaluronic acid (Cystistat, Bioniche Life Sciences Inc.) has been given once weekly for 4 weeks then monthly for 4-5 months. Also, 50 mL of solution containing hyaluronic acid and chondroitin sulfate (iAluRil, IBSA Farmaceutici) has been given once weekly for 4 weeks, then every other week or once monthly for up to 5 months.

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