Last updated on RxList: 9/11/2008
Hycotuss Side Effects Center

Last reviewed on RxList 1/29/2016

Hycotuss (hydrocodone bitartrate and guaifenesin) Expectorant Syrup is a combination of an opiod antitussive and an expectorant used for the symptomatic relief of irritating nonproductive cough associated with upper and lower respiratory tract congestion. Hycotuss may be available in generic form. Common side effects of Hycotuss include low blood pressure, heart palpitations, slowed breathing, drowsiness, dizziness, lightheadedness, anxiety, mood changes, weakness, nausea, vomiting, upset stomach, constipation, and dry mouth.

The usual adult dose of Hycotuss is one teaspoonful (5 mL) after meals and at bedtime, not less than 4 hours apart (not to exceed 6 teaspoonfuls in a 24 hour period). Hycotuss may interact with opioids, analgesics, general anesthetics, phenothiazines, other tranquilizers, sedative hypnotics, or other CNS depressants (including alcohol). Tell your doctor all medications and supplements you use. During pregnancy, Hycotuss should be used only if prescribed. Babies born to mothers who have been taking opioids prior to delivery will be physically dependent. Tell your doctor if your newborn shows withdrawal signs such as irritability and excessive crying, tremors, hyperactive reflexes, increased respiratory rate, increased stools, sneezing, yawning, vomiting and fever. It is unknown if this drug passes into breast milk. Because of the potential for serious reactions in a nursing baby, consult your doctor before breastfeeding. Withdrawal symptoms may occur if you suddenly stop taking this medication.

Our Hycotuss (hydrocodone bitartrate and guaifenesin) Expectorant Syrup Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Hycotuss Professional Information


Respiratory System: Hydrocodone produces dose-related respiratory depression by acting directly on brain stem respiratory centers.

Cardiovascular System: Hypertension, postural hypotension and palpitations.

Genitourinary System: Ureteral spasm, spasm of vesical sphincters and urinary retention have been reported with opiates.

Central Nervous System: Sedation, drowsiness, mental clouding, lethargy, impairment of mental and physical performance, anxiety, fear, dysphoria, dizziness, psychic dependence, mood changes and blurred vision.

Gastrointestinal System: Nausea and vomiting occur more frequently in ambulatory than in recumbent patients.

Drug Abuse And Dependence

Special care should be exercised in prescribing hydrocodone for emotionally unstable patients and for those with a history of drug misuse. Such patients should be closely supervised when long-term therapy is contemplated.

HYCOTUSS (hydrocodone bitartrate and guaifenesin) Expectorant Syrup is a Schedule III opioid. Psychic dependence, physical dependence and tolerance may develop upon repeated administration of opioids; therefore, HYCOTUSS (hydrocodone bitartrate and guaifenesin) Expectorant Syrup should always be prescribed and administered with caution. Physical dependence is the condition in which continued administration of the drug is required to prevent the appearance of a withdrawal syndrome.

Patients physically dependent on opioids will develop an abstinence syndrome upon abrupt discontinuation of the opioid or following the administration of a opioid antagonist. The character and severity of the withdrawal symptoms are related to the degree of physical dependence. Manifestations of opioid withdrawal are similar to but milder than that of morphine and include lacrimation, rhinorrhea, yawning, sweating, restlessness, dilated pupils, anorexia, gooseflesh, irritability and tremor. In more severe forms, nausea, vomiting, intestinal spasm and diarrhea, increased heart rate and blood pressure, chills, and pains in bones and muscles of the back and extremities may occur. Peak effects will usually be apparent at 48 to 72 hours.

Treatment of withdrawal is usually managed by providing sufficient quantities of an opioid to suppress severe withdrawal symptoms and then gradually reducing the dose of opioid over a period of several days.

Read the entire FDA prescribing information for Hycotuss (Hydrocodone Bitartrate and Guaifenesin)


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© Hycotuss Patient Information is supplied by Cerner Multum, Inc. and Hycotuss Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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