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Last reviewed on RxList: 9/7/2018
Hydase Side Effects Center

Last reviewed on RxList 9/7/2018

Hydase (hyaluronidase injection) is an endoglycosidase indicated as an adjuvant to increase the absorption and dispersion of other injected drugs, for hypodermoclysis, and in subcutaneous urography for improving resorption of radiopaque agents. Common side effects of Hydase include:

  • injection site reactions, and
  • allergic reactions:
    • itching,
    • swelling of the lips/around the eyes/skin, or
    • anaphylactic-like reactions

Dose of Hydase is individualized based on the specific use and the patient's clinical state. Hydase may interact with furosemide, benzodiazepines, phenytoin, dopamine, alpha agonist drugs, local anesthetic, salicylates, cortisone, ACTH, estrogens, or antihistamines. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or become pregnant before receiving Hydase. It is unknown if Hydase would affect a fetus. It is unknown if Hydase passes into breast milk. Consult your doctor before breastfeeding.

Our Hydase (hyaluronidase injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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The most frequently reported adverse experiences have been local injection site reactions.

Hyaluronidase has been reported to enhance the adverse events associated with co-administered drug products. Edema has been reported most frequently in association with hypodermoclysis.

Allergic reactions (urticaria, angioedema) have been reported in less than 0.1% of patients receiving hyaluronidase. Anaphylactic-like reactions following retrobulbar block or intravenous injections have occurred, rarely.

Read the entire FDA prescribing information for Hydase (Hyaluronidase Injection)


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© Hydase Patient Information is supplied by Cerner Multum, Inc. and Hydase Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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