Hydase Side Effects Center

Last updated on RxList: 8/22/2022
Hydase Side Effects Center

What Is Hydase?

Hydase (hyaluronidase injection) is an endoglycosidase indicated as an adjuvant to increase the absorption and dispersion of other injected drugs, for hypodermoclysis, and in subcutaneous urography for improving resorption of radiopaque agents.

What Are Side Effects of Hydase?

Common side effects of Hydase include:

  • injection site reactions, and
  • allergic reactions:
    • itching,
    • swelling of the lips/around the eyes/skin, or
    • anaphylactic-like reactions

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Hydase

Dose of Hydase is individualized based on the specific use and the patient's clinical state.

What Drugs, Substances, or Supplements Interact with Hydase?

Hydase may interact with furosemide, benzodiazepines, phenytoin, dopamine, alpha agonist drugs, local anesthetic, salicylates, cortisone, ACTH, estrogens, or antihistamines. Tell your doctor all medications and supplements you use.

Hydase During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or become pregnant before receiving Hydase. It is unknown if Hydase would affect a fetus. It is unknown if Hydase passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Hydase (hyaluronidase injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Hydase Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • swelling in your hands, feet, or other body areas; or
  • pain, swelling, itching, or redness where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Hydase Professional Information


The most frequently reported adverse experiences have been local injection site reactions.

Hyaluronidase has been reported to enhance the adverse events associated with co-administered drug products. Edema has been reported most frequently in association with hypodermoclysis.

Allergic reactions (urticaria, angioedema) have been reported in less than 0.1% of patients receiving hyaluronidase. Anaphylactic-like reactions following retrobulbar block or intravenous injections have occurred, rarely.

Read the entire FDA prescribing information for Hydase (Hyaluronidase Injection)

© Hydase Patient Information is supplied by Cerner Multum, Inc. and Hydase Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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