Reviewed on 11/18/2022

What Is Hydrocortisone-Ciprofloxacin and How Does It Work?

Hydrocortisone-Ciprofloxacin is a combination medication used for the treatment of acute otitis externa. 

What Are Side Effects Associated with Using Hydrocortisone-Ciprofloxacin?

Common side effects of Hydrocortisone-Ciprofloxacin include:

  • itching or pain after using the ear drops;
  • fussiness or irritability;
  • headache; or
  • stuffy nose and sore throat.

Serious side effects of Hydrocortisone-Ciprofloxacin include:

  • hives,
  • difficult breathing,
  • swelling of the face, lips, tongue, or throat,
  • a skin rash
  • new ear drainage with severe itching

Rare side effects of Hydrocortisone-Ciprofloxacin include:

  • migraine,
  • a diminished sensation of touch,
  • numbness and tingling,
  • fungal dermatitis,
  • cough,
  • rash,
  • hives, and
  • hair loss.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

What Are Dosages of Hydrocortisone-Ciprofloxacin?

Adult and pediatric dosage


  • 0.2%/1%

Acute Otitis Externa

Adult dosage

  • 3 drops in the affected ear every 12 hours for 7 days

Pediatric dosage

Below 1  year

  • Safety and efficacy not established

Above 1 year

  • 3 drops in the affected ear every 12 hours for 7 days

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

What Other Drugs Interact with Hydrocortisone-Ciprofloxacin?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Hydrocortisone-Ciprofloxacin has severe interactions with the following drugs:
  • Hydrocortisone-Ciprofloxacin has serious interactions with at least 145 other drugs.
  • Hydrocortisone-Ciprofloxacin has moderate interactions with at least 424 other drugs.
  • Hydrocortisone-Ciprofloxacin has minor interactions with atleast 168 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

What Are Warnings and Precautions for Hydrocortisone-Ciprofloxacin?


  • Hypersensitivity to drugs or components
  • Tympanic membrane perforation (nonsterile preparation)
  • Viral infections of the external canal including varicella & herpes simplex infections

Effects of drug abuse

  • None

Short-Term Effects

  • See “What Are Side Effects Associated with Using Hydrocortisone-Ciprofloxacin?”

Long-Term Effects

  • See “What Are Side Effects Associated with Using Hydrocortisone-Ciprofloxacin?”


  • Not for ophthalmic use or injection
  • Prolonged use may result in bacterial or fungal overgrowth
  • Resistance to the product may develop
  • If the infection has not improved after one week of therapy, cultures should be obtained to guide further treatment
  • Discontinue at the first appearance of skin rash or any other sign of hypersensitivity; serious and occasionally fatal hypersensitivity (anaphylactic) reactions, some following the first dose, reported in patients receiving systemic quinolones; serious acute hypersensitivity reactions may require immediate emergency treatment
  • The dropper cap contains natural rubber (latex) which may cause severe allergic reactions

Pregnancy & Lactation

  • Use with caution if the benefits outweigh the risks during pregnancy
  • Lactation
    • Excretion in breast milk unknown; not recommended

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