Hydrocortisone Side Effects Center

Last updated on RxList: 6/23/2022
Hydrocortisone Side Effects Center

What Is Hydrocortisone?

Hydrocortisone (hydrocortisone) Cream 2.5% is a topical (for the skin) steroid used to treat inflammation of the skin caused by a number of conditions such as allergic reactions, eczema, or psoriasis.

  • Hydrocortisone is available in generic form.

What Are Side Effects of Hydrocortisone?

Common side effects of Hydrocortisone Cream include

Hydrocortisone may cause serious side effects including:

  • blurred vision,
  • tunnel vision,
  • eye pain,
  • seeing halos around lights,
  • muscle weakness,
  • loss of muscle mass,
  • new or unusual pain in your joints, bones, or muscles,
  • severe headaches,
  • ringing in your ears,
  • pain behind your eyes,
  • unusual changes in mood or behavior,
  • convulsions (a seizure),
  • shortness of breath,
  • swelling,
  • rapid weight gain (especially in your face and midsection),
  • fever,
  • chills,
  • cough,
  • trouble breathing,
  • sores in your mouth or on your skin,
  • diarrhea,
  • burning when you urinate,
  • slow wound healing,
  • skin discoloration,
  • thinning skin,
  • increased body hair,
  • tiredness,
  • menstrual changes,
  • sexual changes,
  • weakness,
  • tiredness,
  • nausea,
  • menstrual changes,
  • skin discoloration,
  • craving salty foods, and
  • lightheadedness

Tell your doctor if you have any serious side effects of Hydrocortisone Cream listed above.

Dosage for Hydrocortisone

Dose and administration: Apply hydrocortisone cream to the affected area as a thin film 2 to 4 times daily depending on the severity of the condition.

What Drugs, Substances, or Supplements Interact with Hydrocortisone?

It is not likely other drugs you take orally or inject will have an effect on topically applied hydrocortisone. But many drugs can interact with each other. Tell your doctor all prescription and over-the-counter medications and supplements you use.

During pregnancy, hydrocortisone should be used only when prescribed. Infants born to mothers who have been using this medication for an extended period of time may have hormone problems.

Tell your doctor if you notice symptoms such as persistent nausea/vomiting, severe diarrhea, or weakness in your newborn.

Hydrocortisone During Pregnancy or Breastfeeding

This medication passes into breast milk. However, this drug is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Additional Information

Our Hydrocortisone (hydrocortisone) Cream 2.5% Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Allergies can best be described as: See Answer
Hydrocortisone Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • worsening of your skin condition;
  • redness, warmth, swelling, oozing, or severe irritation of any treated skin;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or
  • possible signs of absorbing this medicine through your skin--weight gain (especially in your face or your upper back and torso), slow wound healing, thinning or discolored skin, increased body hair, muscle weakness, nausea, diarrhea, tiredness, mood changes, menstrual changes, sexual changes.

Less serious side effects may be more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Could I Be Allergic? Discover Your Allergy Triggers See Slideshow
Hydrocortisone Professional Information


No information provided.

Please see WARNINGS Section.

Read the entire FDA prescribing information for Hydrocortisone (Hydrocortisone Cream and Ointment 2.5%)

© Hydrocortisone Patient Information is supplied by Cerner Multum, Inc. and Hydrocortisone Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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