Hylenex

Last reviewed on RxList: 7/26/2018
Hylenex Side Effects Center

Last reviewed on RxList 7/26/2018

Hylenex recombinant (hyaluronidase human injection) is a genetically designed protein used as an aid in helping the body absorb other injected medications. Hylenex is also used to help contrast dyes in the body show more clearly on certain types of x-rays or scans. Common side effects of Hylenex include:

  • injection site reactions (pain, itching, redness, swelling, or tenderness),
  • swelling in any part of the body, and
  • allergic reactions such as hives

Hylenex is administered as a subcutaneous (under the skin) injection. Dose is determined by a physician. Hylenex may interact with furosemide, phenytoin, sedatives or anxiety medications, aspirin or salicylates, cortisone or ACTH, estrogens, or antihistamines. Tell your doctor all medications and supplements you use. During pregnancy, Hylenex should be used only if prescribed. It is unknown if it is harmful to a fetus. It is not known if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Our Hylenex recombinant (hyaluronidase human injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Hylenex Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • swelling in your hands, feet, or other body areas; or
  • pain, swelling, itching, or redness where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Hylenex (Hyaluronidase Human Injection)

QUESTION

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Hylenex Professional Information

SIDE EFFECTS

The following adverse reactions have been identified during post-approval use of hyaluronidase products. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

The most frequently reported adverse reactions have been mild local injection site reactions such as erythema and pain. Hyaluronidase has been reported to enhance the adverse reactions associated with co-administered drug products. Edema has been reported most frequently in association with subcutaneous fluid administration. Allergic reactions (urticaria or angioedema) have been reported in less than 0.1% of patients receiving hyaluronidase. Anaphylactic-like reactions following retrobulbar block or intravenous injections have occurred, rarely.

Read the entire FDA prescribing information for Hylenex (Hyaluronidase Human Injection)

© Hylenex Patient Information is supplied by Cerner Multum, Inc. and Hylenex Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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