Hylenex Side Effects Center

Last updated on RxList: 8/22/2022
Hylenex Side Effects Center

What Is Hylenex?

Hylenex recombinant (hyaluronidase human injection) is a genetically designed protein used as an aid in helping the body absorb other injected medications. Hylenex is also used to help contrast dyes in the body show more clearly on certain types of x-rays or scans.

What Are Side Effects of Hylenex?

Common side effects of Hylenex include:

  • injection site reactions (pain, itching, redness, swelling, or tenderness),
  • swelling in any part of the body, and
  • allergic reactions such as hives

Hylenex may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • swelling in your hands, feet, or other body areas, and
  • pain, swelling, itching, or redness where the injection was given

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Hylenex

Hylenex is administered as a subcutaneous (under the skin) injection. Dose is determined by a physician.

What Drugs, Substances, or Supplements Interact with Hylenex?

Hylenex may interact with furosemide, phenytoin, sedatives or anxiety medications, aspirin or salicylates, cortisone or ACTH, estrogens, or antihistamines. Tell your doctor all medications and supplements you use.

Hylenex During Pregnancy or Breastfeeding

During pregnancy, Hylenex should be used only if prescribed. It is unknown if it is harmful to a fetus. It is not known if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Additional Information

Our Hylenex recombinant (hyaluronidase human injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Hylenex Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • swelling in your hands, feet, or other body areas; or
  • pain, swelling, itching, or redness where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Hylenex Professional Information

SIDE EFFECTS

The following adverse reactions have been identified during post-approval use of hyaluronidase products. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

The most frequently reported adverse reactions have been mild local injection site reactions such as erythema and pain. Hyaluronidase has been reported to enhance the adverse reactions associated with co-administered drug products. Edema has been reported most frequently in association with subcutaneous fluid administration. Allergic reactions (urticaria or angioedema) have been reported in less than 0.1% of patients receiving hyaluronidase. Anaphylactic-like reactions following retrobulbar block or intravenous injections have occurred, rarely.

Read the entire FDA prescribing information for Hylenex (Hyaluronidase Human Injection)

© Hylenex Patient Information is supplied by Cerner Multum, Inc. and Hylenex Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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