Hyper-: Prefix meaning high, beyond, excessive, or above normal, as in hyperglycemia (high sugar in the blood) and hypercalcemia (high calcium in the blood). The opposite of hyper- is hypo-. SLIDESHOW Heart Disease: Causes of a Heart Attack See Slideshow From Healthy Resources 10 Rheumatoid Arthritis SymptomsWhat Is Exocrine Pancreatic Insufficiency?Understanding COVID-19 Testing and Treatment Featured Centers What Are the Best PsA Treatments for You?Understanding Biologics 10 Things People With Depression Wish You Knew Health Solutions From Our Sponsors Shot-Free MS Treatment Your Child and COVID-19