Hypertonic Saline Side Effects Center

Last updated on RxList: 3/2/2021
Hypertonic Saline Side Effects Center

What Is Hypertonic Saline?

Hypertonic Saline 3% and 5% Sodium Chloride Injection is an electrolyte and fluid replenisher used as a source of water and electrolytes. Hypertonic saline 3% and 5% sodium chloride is available in generic form.

What Are Side Effects of Hypertonic Saline?

Common side effects of hypertonic saline 3% and 5% sodium chloride include:

  • fever,
  • infection at injection site, or
  • redness/red streaking and swelling from the site of injection.

Dosage for Hypertonic Saline

Dosage of Hypertonic Saline is dependent upon the age, weight, and clinical condition of the patient as well as laboratory determinations.

What Drugs, Substances, or Supplements Interact with Hypertonic Saline?

Other drugs may affect Hypertonic Saline. Tell your doctor about all the prescription and over-the-counter medications and supplements you use.

Hypertonic Saline During Pregnancy and Breastfeeding

Hypertonic Saline should be given to a pregnant woman only if prescribed. Consult your doctor before breastfeeding.

Additional Information

Our Hypertonic Saline 3% and 5% Sodium Chloride Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


According to the USDA, there is no difference between a “portion” and a “serving.” See Answer
Hypertonic Saline Professional Information


Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia.

If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures, and save the remainder of the fluid for examination if deemed necessary.

Read the entire FDA prescribing information for Hypertonic Saline (3% and 5% Sodium Chloride Injection)


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© Hypertonic Saline Patient Information is supplied by Cerner Multum, Inc. and Hypertonic Saline Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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