Slideshows Images Quizzes

Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. See additional information.

Ibsrela vs. Linzess

Reviewed on 9/25/2019

Are Ibsrela and Linzess the Same Thing?

Ibsrela (tenapanor) and Linzess (linaclotide) are used to treat irritable bowel syndrome with constipation (IBS-C) in adults.

Linzess is also used to treat chronic idiopathic constipation (CIC) in adults.

Ibsrela and Linzess belong to different drug classes. Ibsrela is a sodium/hydrogen exchanger 3 (NHE3) inhibitor and Linzess is a guanylate cyclase-C agonist.

Side effects of Ibsrela and Linzess that are similar include diarrhea, abdominal distension/bloating, and gas (flatulence).

Side effects of Ibsrela that are different from Linzess include dizziness.

Side effects of Linzess that are different from Ibsrela include stomach/abdominal pain or discomfort, heartburn, vomiting, headache, and cold symptoms such as stuffy nose, sneezing, or sinus pain.

Both Ibsrela and Linzess may interact with other drugs.

What Are Possible Side Effects of Ibsrela?

Common side effects of Ibsrela include:

  • diarrhea,
  • abdominal distension,
  • gas (flatulence), and
  • dizziness.

What Are Possible Side Effects of Linzess?

Common side effects of Linzess include:

  • diarrhea,
  • stomach/abdominal pain or discomfort,
  • gas,
  • bloating,
  • heartburn,
  • vomiting,
  • headache, or
  • cold symptoms such as stuffy nose, sneezing, or sinus pain.

What Is Ibsrela?

Ibsrela (tenapanor) is a sodium/hydrogen exchanger 3 (NHE3) inhibitor indicated for treatment of irritable bowel syndrome with constipation (IBS-C) in adults.

What Is Linzess?

Linzess (linaclotide) is a guanylate cyclase-C agonist used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.

QUESTION

What is irritable bowel syndrome or IBS? See Answer

What Drugs Interact With Ibsrela?

Ibsrela may interact with other drugs. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Ibsrela; maternal use is not expected to result in fetal exposure to the drug. It is unknown if Ibsrela passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Linzess?

Linzess may interact with other drugs.

How Should Ibsrela Be Taken?

The recommended dosage of Ibsrela in adults is 50 mg, orally twice daily.

How Should Linzess Be Taken?

The recommended dose of Linzess for those with irritable bowel syndrome (IBS) is 290 mcg taken once a day on an empty stomach, at least 30 minutes before the first meal of the day. The same applies for those with chronic idiopathic constipation only the dosage is 145 mcg. Pediatric patients under the age of 17 should not take Linzess.

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References

FDA. Ibsrela Drug Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211801s000lbl.pdf

Allergan/Ironwood. Linzess Product Information.

https://www.linzess.com
CONTINUE SCROLLING FOR RELATED SLIDESHOW

Health Solutions From Our Sponsors