Ibsrela vs. Trulance

Are Ibsrela and Trulance the Same Thing?

Ibsrela (tenapanor) and Trulance (plecanatide) are used to treat different types of constipation.

Ibsrela is used to treat irritable bowel syndrome with constipation (IBS-C) in adults.

Trulance is used to treat chronic idiopathic constipation (CIC).

Ibsrela and Trulance belong to different drug classes. Ibsrela is a sodium/hydrogen exchanger 3 (NHE3) and Trulance is a guanylate cyclase-C agonist.

Side effects of Ibsrela and Trulance that are similar include diarrhea, abdominal distension/bloating, and gas (flatulence).

Side effects of Ibsrela that are different from Trulance include dizziness.

Side effects of Trulance that are different from Ibsrela include sinus infection, upper respiratory tract infection, abdominal tenderness, and increased liver biochemical tests.

Both Ibsrela and Trulance may interact with other drugs.

What Are Possible Side Effects of Ibsrela?

Common side effects of Ibsrela include:

  • diarrhea,
  • abdominal distension,
  • gas (flatulence), and
  • dizziness.

What Are Possible Side Effects of Trulance?

Common side effects of Trulance include:

  • diarrhea (may be severe),
  • sinus infection,
  • upper respiratory tract infection,
  • bloating,
  • gas,
  • abdominal tenderness, and
  • increased liver biochemical tests.

What Is Ibsrela?

Ibsrela (tenapanor) is a sodium/hydrogen exchanger 3 (NHE3) inhibitor indicated for treatment of irritable bowel syndrome with constipation (IBS-C) in adults.

What Is Trulance?

Trulance (plecanatide) tablets, for oral use is a guanylate cyclase-C agonist indicated in adults for treatment of chronic idiopathic constipation (CIC).


Digestive Disorders: Common Misconceptions See Slideshow

What Drugs Interact With Ibsrela?

Ibsrela may interact with other drugs. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Ibsrela; maternal use is not expected to result in fetal exposure to the drug. It is unknown if Ibsrela passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Trulance?

Trulance may interact with other drugs.

How Should Ibsrela Be Taken?

The recommended dosage of Ibsrela in adults is 50 mg, orally twice daily.

How Should Trulance Be Taken?

The recommended adult dosage of Trulance is 3 mg taken orally once daily.


What is irritable bowel syndrome or IBS? See Answer

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FDA. Ibsrela Drug Information.


Synergy Pharmaceuticals Inc. Trulance Product Information.


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