Ibsrela vs. Xifaxan

Are Ibsrela and Xifaxan the Same Thing?

Ibsrela (tenapanor) and Xifaxan (rifaximin) are used to treat different symptoms of irritable bowel syndrome (IBS).

Ibsrela is used to treat irritable bowel syndrome with constipation (IBS-C) in adults.

Xifaxan is used to treat irritable bowel syndrome with diarrhea (IBS-D). Xifaxan is also used to treat patients 12 years of age and older with travelers' diarrhea caused by noninvasive strains of Escherichia coli (E. coli), and to lower the risk of worsened brain function, or hepatic encephalopathy, in adults with liver failure.

Ibsrela and Xifaxan belong to different drug classes. Ibsrela is a sodium/hydrogen exchanger 3 (NHE3) inhibitor and Xifaxan is an antibiotic.

Side effects of Ibsrela and Xifaxan that are similar include abdominal distension/bloating, gas (flatulence), and dizziness.

Side effects of Ibsrela that are different from Xifaxan include diarrhea.

Side effects of Xifaxan that are different from Ibsrela include nausea, vomiting, constipation, stomach pain, feeling like you need to urgently empty your bowel, feeling your bowel is not completely empty, headache, tired feeling, and swelling in your hands, feet, or torso.

Ibsrela may interact with other drugs.

Xifaxan may interact with cyclosporine, ketoconazole, warfarin, other antibiotics, antiviral medicines, and heart or blood pressure medicines.

What Are Possible Side Effects of Ibsrela?

Common side effects of Ibsrela include:

  • diarrhea,
  • abdominal distension,
  • gas (flatulence), and
  • dizziness.

What Are Possible Side Effects of Xifaxan?

Common side effects of Xifaxan include:

  • nausea,
  • vomiting,
  • constipation,
  • bloating,
  • gas,
  • stomach pain,
  • feeling like you need to urgently empty your bowel,
  • feeling your bowel is not completely empty,
  • headache,
  • dizziness,
  • tired feeling, or
  • swelling in your hands, feet, or torso.

Tell your doctor if you develop serious side effects of Xifaxan including:

  • persistent diarrhea,
  • abdominal or stomach pain or cramping, or
  • blood or mucus in your stool.

What Is Ibsrela?

Ibsrela (tenapanor) is a sodium/hydrogen exchanger 3 (NHE3) inhibitor indicated for treatment of irritable bowel syndrome with constipation (IBS-C) in adults.

What Is Xifaxan?

Xifaxan (rifaximin) is an antibiotic indicated for the treatment of patients 12 years of age and older with travelers' diarrhea caused by noninvasive strains of Escherichia coli (E. coli), and to lower the risk of worsened brain function, or hepatic encephalopathy, in adults with liver failure.

QUESTION

What is irritable bowel syndrome or IBS? See Answer

What Drugs Interact With Ibsrela?

Ibsrela may interact with other drugs. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Ibsrela; maternal use is not expected to result in fetal exposure to the drug. It is unknown if Ibsrela passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Xifaxan?

Xifaxan may interact with other drugs. Tell your doctor all medications and supplements you use.

How Should Ibsrela Be Taken?

The recommended dosage of Ibsrela in adults is 50 mg, orally twice daily.

How Should Xifaxan Be Taken?

Xifaxan (rifaximin) tablets for oral administration are film-coated and contain 200 or 550 mg of rifaximin. Usual dosage is 200 mg three times a day for three days for diarrhea and 550mg twice a day for 3 days for hepatic encephalopathy.

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References

FDA. Ibsrela Drug Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211801s000lbl.pdf

Salix Pharmaceuticals. Xifaxan Drug Information.

https://www.xifaxan.com

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